Cargando…
Mutant C/EBPα p30 alleviates immunosuppression of CD8(+) T cells by inhibiting autophagy‐associated secretion of IL‐1β in AML
OBJECTIVES: Mutant C/EBPα p30 (mp30), the product of C/EBPα double mutations (DM), lacks transactivation domain 1 and has C‐terminal loss‐of‐function mutation. Acute myeloid leukaemia (AML) patients harbouring C/EBPα DM could be classified as a distinct subgroup with favourable prognosis. However, t...
Autores principales: | Wang, Jun‐Dan, Xu, Jue‐Qiong, Zhang, Xue‐Ning, Huang, Ze‐Wei, Liu, Ling‐Ling, Zhang, Ling, Lei, Xin‐Xing, Xue, Man‐Jie, Weng, Jian‐Yu, Long, Zi‐Jie |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715362/ https://www.ncbi.nlm.nih.gov/pubmed/36124714 http://dx.doi.org/10.1111/cpr.13331 |
Ejemplares similares
-
STAT5 promotes PD-L1 expression by facilitating histone lactylation to drive immunosuppression in acute myeloid leukemia
por: Huang, Ze-Wei, et al.
Publicado: (2023) -
Initiation of MLL-rearranged AML is dependent on C/EBPα
por: Ohlsson, Ewa, et al.
Publicado: (2014) -
The AML-associated K313 mutation enhances C/EBPα activity by leading to C/EBPα overexpression
por: Gentle, Ian Edward, et al.
Publicado: (2021) -
C/EBPβ cooperates with MYB to maintain the oncogenic program of AML cells
por: Klempnauer, Karl-Heinz
Publicado: (2023) -
Emodin reactivated autophagy and alleviated inflammatory lung injury in mice
with lethal endotoxemia
por: Dong, Yan, et al.
Publicado: (2019)