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Mitophagy: A novel perspective for insighting into cancer and cancer treatment

BACKGROUND: Mitophagy refers to the selective self‐elimination of mitochondria under damaged or certain developmental conditions. As an important regulatory mechanism to remove damaged mitochondria and maintain the internal and external cellular balance, mitophagy plays pivotal roles in carcinogenes...

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Detalles Bibliográficos
Autores principales: Song, Congkuan, Pan, Shize, Zhang, Jinjin, Li, Ning, Geng, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715364/
https://www.ncbi.nlm.nih.gov/pubmed/36200262
http://dx.doi.org/10.1111/cpr.13327
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author Song, Congkuan
Pan, Shize
Zhang, Jinjin
Li, Ning
Geng, Qing
author_facet Song, Congkuan
Pan, Shize
Zhang, Jinjin
Li, Ning
Geng, Qing
author_sort Song, Congkuan
collection PubMed
description BACKGROUND: Mitophagy refers to the selective self‐elimination of mitochondria under damaged or certain developmental conditions. As an important regulatory mechanism to remove damaged mitochondria and maintain the internal and external cellular balance, mitophagy plays pivotal roles in carcinogenesis and progression as well as treatment. MATERIALS AND METHODS: Here, we combined data from recent years to comprehensively describe the regulatory mechanisms of mitophagy and its multifaceted significance in cancer, and discusse the potential of targeted mitophagy as a cancer treatment strategy. RESULTS: The molecular mechanisms regulating mitophagy are complex, diverse, and cross‐talk. Inducing or blocking mitophagy has the same or completely different effects in different cancer contexts. Mitophagy plays an indispensable role in regulating cancer metabolic reprogramming, cell stemness, and chemotherapy resistance for better adaptation to tumor microenvironment. In cancer cell biology, mitophagy is considered to be a double‐edged sword. And to fully understand the role of mitophagy in cancer development can provide new targets for cancer treatment in clinical practice. CONCLUSIONS: This review synthesizes a large body of data to comprehensively describe the molecular mechanisms of mitophagy and its multidimensional significance in cancer and cancer treatment, which will undoubtedly deepen the understanding of mitophagy.
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spelling pubmed-97153642022-12-02 Mitophagy: A novel perspective for insighting into cancer and cancer treatment Song, Congkuan Pan, Shize Zhang, Jinjin Li, Ning Geng, Qing Cell Prolif Reviews BACKGROUND: Mitophagy refers to the selective self‐elimination of mitochondria under damaged or certain developmental conditions. As an important regulatory mechanism to remove damaged mitochondria and maintain the internal and external cellular balance, mitophagy plays pivotal roles in carcinogenesis and progression as well as treatment. MATERIALS AND METHODS: Here, we combined data from recent years to comprehensively describe the regulatory mechanisms of mitophagy and its multifaceted significance in cancer, and discusse the potential of targeted mitophagy as a cancer treatment strategy. RESULTS: The molecular mechanisms regulating mitophagy are complex, diverse, and cross‐talk. Inducing or blocking mitophagy has the same or completely different effects in different cancer contexts. Mitophagy plays an indispensable role in regulating cancer metabolic reprogramming, cell stemness, and chemotherapy resistance for better adaptation to tumor microenvironment. In cancer cell biology, mitophagy is considered to be a double‐edged sword. And to fully understand the role of mitophagy in cancer development can provide new targets for cancer treatment in clinical practice. CONCLUSIONS: This review synthesizes a large body of data to comprehensively describe the molecular mechanisms of mitophagy and its multidimensional significance in cancer and cancer treatment, which will undoubtedly deepen the understanding of mitophagy. John Wiley and Sons Inc. 2022-10-05 /pmc/articles/PMC9715364/ /pubmed/36200262 http://dx.doi.org/10.1111/cpr.13327 Text en © 2022 The Authors. Cell Proliferation published by Beijing Institute for Stem Cell and Regenerative Medicine and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Song, Congkuan
Pan, Shize
Zhang, Jinjin
Li, Ning
Geng, Qing
Mitophagy: A novel perspective for insighting into cancer and cancer treatment
title Mitophagy: A novel perspective for insighting into cancer and cancer treatment
title_full Mitophagy: A novel perspective for insighting into cancer and cancer treatment
title_fullStr Mitophagy: A novel perspective for insighting into cancer and cancer treatment
title_full_unstemmed Mitophagy: A novel perspective for insighting into cancer and cancer treatment
title_short Mitophagy: A novel perspective for insighting into cancer and cancer treatment
title_sort mitophagy: a novel perspective for insighting into cancer and cancer treatment
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715364/
https://www.ncbi.nlm.nih.gov/pubmed/36200262
http://dx.doi.org/10.1111/cpr.13327
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