Critical diagnostic and cancer stem cell markers in neoplastic cells from canine primary and xenografted pulmonary adenocarcinoma

It is challenging to diagnose metastatic tumors whose cellular morphology is different from the primary. We characterized canine primary pulmonary adenocarcinoma (PAC) and its xenografted tumors by histological and immunohistochemical analyses for critical diagnostic and cancer stem cell (CSC) marke...

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Autores principales: Tangchang, Warisraporn, Kim, Yun-Hyeok, Oh, Ye-In, Lee, Byung-Woo, Kim, Hyunwook, Yoon, Byungil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Veterinary Science 2022
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715391/
https://www.ncbi.nlm.nih.gov/pubmed/36448435
http://dx.doi.org/10.4142/jvs.22124
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author Tangchang, Warisraporn
Kim, Yun-Hyeok
Oh, Ye-In
Lee, Byung-Woo
Kim, Hyunwook
Yoon, Byungil
author_facet Tangchang, Warisraporn
Kim, Yun-Hyeok
Oh, Ye-In
Lee, Byung-Woo
Kim, Hyunwook
Yoon, Byungil
author_sort Tangchang, Warisraporn
collection PubMed
description It is challenging to diagnose metastatic tumors whose cellular morphology is different from the primary. We characterized canine primary pulmonary adenocarcinoma (PAC) and its xenografted tumors by histological and immunohistochemical analyses for critical diagnostic and cancer stem cell (CSC) markers. To generate a tumor xenograft model, we subsequently transplanted the tissue pieces from the PAC into athymic nude mice. Immunohistochemical examination was performed for diagnostic (TTF-1, Napsin A, and SP-A) and CSC markers (CD44 and CD133). The use of CSC markers together with diagnostic markers can improve the detection and diagnosis of canine primary and metastatic adenocarcinomas.
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spelling pubmed-97153912022-12-13 Critical diagnostic and cancer stem cell markers in neoplastic cells from canine primary and xenografted pulmonary adenocarcinoma Tangchang, Warisraporn Kim, Yun-Hyeok Oh, Ye-In Lee, Byung-Woo Kim, Hyunwook Yoon, Byungil J Vet Sci Rapid Communication It is challenging to diagnose metastatic tumors whose cellular morphology is different from the primary. We characterized canine primary pulmonary adenocarcinoma (PAC) and its xenografted tumors by histological and immunohistochemical analyses for critical diagnostic and cancer stem cell (CSC) markers. To generate a tumor xenograft model, we subsequently transplanted the tissue pieces from the PAC into athymic nude mice. Immunohistochemical examination was performed for diagnostic (TTF-1, Napsin A, and SP-A) and CSC markers (CD44 and CD133). The use of CSC markers together with diagnostic markers can improve the detection and diagnosis of canine primary and metastatic adenocarcinomas. The Korean Society of Veterinary Science 2022-10-21 /pmc/articles/PMC9715391/ /pubmed/36448435 http://dx.doi.org/10.4142/jvs.22124 Text en © 2022 The Korean Society of Veterinary Science https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Rapid Communication
Tangchang, Warisraporn
Kim, Yun-Hyeok
Oh, Ye-In
Lee, Byung-Woo
Kim, Hyunwook
Yoon, Byungil
Critical diagnostic and cancer stem cell markers in neoplastic cells from canine primary and xenografted pulmonary adenocarcinoma
title Critical diagnostic and cancer stem cell markers in neoplastic cells from canine primary and xenografted pulmonary adenocarcinoma
title_full Critical diagnostic and cancer stem cell markers in neoplastic cells from canine primary and xenografted pulmonary adenocarcinoma
title_fullStr Critical diagnostic and cancer stem cell markers in neoplastic cells from canine primary and xenografted pulmonary adenocarcinoma
title_full_unstemmed Critical diagnostic and cancer stem cell markers in neoplastic cells from canine primary and xenografted pulmonary adenocarcinoma
title_short Critical diagnostic and cancer stem cell markers in neoplastic cells from canine primary and xenografted pulmonary adenocarcinoma
title_sort critical diagnostic and cancer stem cell markers in neoplastic cells from canine primary and xenografted pulmonary adenocarcinoma
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715391/
https://www.ncbi.nlm.nih.gov/pubmed/36448435
http://dx.doi.org/10.4142/jvs.22124
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