SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming

How SARS-CoV-2 penetrates the airway barrier of mucus and periciliary mucins to infect nasal epithelium remains unclear. Using primary nasal epithelial organoid cultures, we found that the virus attaches to motile cilia via the ACE2 receptor. SARS-CoV-2 traverses the mucus layer, using motile cilia...

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Detalles Bibliográficos
Autores principales: Wu, Chien-Ting, Lidsky, Peter V., Xiao, Yinghong, Cheng, Ran, Lee, Ivan T., Nakayama, Tsuguhisa, Jiang, Sizun, He, Wei, Demeter, Janos, Knight, Miguel G., Turn, Rachel E., Rojas-Hernandez, Laura S., Ye, Chengjin, Chiem, Kevin, Shon, Judy, Martinez-Sobrido, Luis, Bertozzi, Carolyn R., Nolan, Garry P., Nayak, Jayakar V., Milla, Carlos, Andino, Raul, Jackson, Peter K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Inc. 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715480/
https://www.ncbi.nlm.nih.gov/pubmed/36580912
http://dx.doi.org/10.1016/j.cell.2022.11.030

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