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Phase I-metabolism studies of the synthetic cannabinoids PX-1 and PX-2 using three different in vitro models

PURPOSE: Synthetic cannabinoids (SCs), highly metabolized substances, are rarely found unmodified in urine samples. Urine screening relies on SC metabolite detection, requiring metabolism knowledge. Metabolism data can be acquired via in vitro assays, e.g., human hepatocytes, pooled human liver micr...

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Detalles Bibliográficos
Autores principales: Dahm, Patrick, Thomas, Andreas, Rothschild, Markus A., Thevis, Mario, Mercer-Chalmers-Bender, Katja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715525/
https://www.ncbi.nlm.nih.gov/pubmed/36454402
http://dx.doi.org/10.1007/s11419-021-00606-6