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Assessment of inner ear morphology and function in response to local positive pressure for Ménière’s disease: a nonrandomized controlled trial
Ménière’s disease (MD) is an inner ear disorder in which the main pathological feature is endolymphatic hydrops (EH). Positive pressure therapy (PPT) using a portable device is now a second-line therapy for intractable MD when initial medical treatment fails. However, it remains unknown whether PPT...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715546/ https://www.ncbi.nlm.nih.gov/pubmed/36456740 http://dx.doi.org/10.1038/s41598-022-25321-z |
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author | Fukushima, Munehisa Akahani, Shiro Okamoto, Hidehiko Takeda, Noriaki Inohara, Hidenori |
author_facet | Fukushima, Munehisa Akahani, Shiro Okamoto, Hidehiko Takeda, Noriaki Inohara, Hidenori |
author_sort | Fukushima, Munehisa |
collection | PubMed |
description | Ménière’s disease (MD) is an inner ear disorder in which the main pathological feature is endolymphatic hydrops (EH). Positive pressure therapy (PPT) using a portable device is now a second-line therapy for intractable MD when initial medical treatment fails. However, it remains unknown whether PPT causes the morphological and functional changes of inner ear in patients with active MD in accordance with reduction of vertigo attacks. In this nonrandomized controlled trial of 52 patients with MD, the volume of EH significantly decreased with reduction of vertigo attacks during 8 months of PPT combined with medications while the volume of that significantly increased with medications alone. There was no difference between Control group (n = 26) and PPT group (n = 26) regarding the vertigo control, however, PPT group achieved a significant functional improvement of vertical semicircular canals. The effect of volume reduction by PPT has been firstly demonstrated and the functional changes of all semicircular canals during PPT have been firstly examined. Morphological and functional changes in the inner ear by administrating local positive pressure are quite different from those caused by medications alone. Clinical trial registration: UMIN-CTR UMIN000041164 (registered on July 20, 2020). |
format | Online Article Text |
id | pubmed-9715546 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-97155462022-12-03 Assessment of inner ear morphology and function in response to local positive pressure for Ménière’s disease: a nonrandomized controlled trial Fukushima, Munehisa Akahani, Shiro Okamoto, Hidehiko Takeda, Noriaki Inohara, Hidenori Sci Rep Article Ménière’s disease (MD) is an inner ear disorder in which the main pathological feature is endolymphatic hydrops (EH). Positive pressure therapy (PPT) using a portable device is now a second-line therapy for intractable MD when initial medical treatment fails. However, it remains unknown whether PPT causes the morphological and functional changes of inner ear in patients with active MD in accordance with reduction of vertigo attacks. In this nonrandomized controlled trial of 52 patients with MD, the volume of EH significantly decreased with reduction of vertigo attacks during 8 months of PPT combined with medications while the volume of that significantly increased with medications alone. There was no difference between Control group (n = 26) and PPT group (n = 26) regarding the vertigo control, however, PPT group achieved a significant functional improvement of vertical semicircular canals. The effect of volume reduction by PPT has been firstly demonstrated and the functional changes of all semicircular canals during PPT have been firstly examined. Morphological and functional changes in the inner ear by administrating local positive pressure are quite different from those caused by medications alone. Clinical trial registration: UMIN-CTR UMIN000041164 (registered on July 20, 2020). Nature Publishing Group UK 2022-12-01 /pmc/articles/PMC9715546/ /pubmed/36456740 http://dx.doi.org/10.1038/s41598-022-25321-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Fukushima, Munehisa Akahani, Shiro Okamoto, Hidehiko Takeda, Noriaki Inohara, Hidenori Assessment of inner ear morphology and function in response to local positive pressure for Ménière’s disease: a nonrandomized controlled trial |
title | Assessment of inner ear morphology and function in response to local positive pressure for Ménière’s disease: a nonrandomized controlled trial |
title_full | Assessment of inner ear morphology and function in response to local positive pressure for Ménière’s disease: a nonrandomized controlled trial |
title_fullStr | Assessment of inner ear morphology and function in response to local positive pressure for Ménière’s disease: a nonrandomized controlled trial |
title_full_unstemmed | Assessment of inner ear morphology and function in response to local positive pressure for Ménière’s disease: a nonrandomized controlled trial |
title_short | Assessment of inner ear morphology and function in response to local positive pressure for Ménière’s disease: a nonrandomized controlled trial |
title_sort | assessment of inner ear morphology and function in response to local positive pressure for ménière’s disease: a nonrandomized controlled trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715546/ https://www.ncbi.nlm.nih.gov/pubmed/36456740 http://dx.doi.org/10.1038/s41598-022-25321-z |
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