Valosin-containing protein (VCP/p97) inhibition reduces viral clearance and induces toxicity associated with muscular damage

Valosin-containing protein (VCP)/p97 has emerged as a central regulator of the ubiquitin–proteasome system by connecting ubiquitylation and degradation. The development of CB-5083, an ATPase D2-domain-selective and orally bioavailable inhibitor of VCP/p97, allows targeting of the ubiquitin–proteasom...

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Detalles Bibliográficos
Autores principales: del Rio Oliva, Marta, Basler, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715549/
https://www.ncbi.nlm.nih.gov/pubmed/36456548
http://dx.doi.org/10.1038/s41419-022-05461-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715549/
https://www.ncbi.nlm.nih.gov/pubmed/36456548
http://dx.doi.org/10.1038/s41419-022-05461-w

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