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Valosin-containing protein (VCP/p97) inhibition reduces viral clearance and induces toxicity associated with muscular damage
Valosin-containing protein (VCP)/p97 has emerged as a central regulator of the ubiquitin–proteasome system by connecting ubiquitylation and degradation. The development of CB-5083, an ATPase D2-domain-selective and orally bioavailable inhibitor of VCP/p97, allows targeting of the ubiquitin–proteasom...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715549/ https://www.ncbi.nlm.nih.gov/pubmed/36456548 http://dx.doi.org/10.1038/s41419-022-05461-w |