Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia

Aberrant self-renewal of leukemia initiation cells (LICs) drives aggressive acute myeloid leukemia (AML). Here, we report that UHRF1, an epigenetic regulator that recruits DNMT1 to methylate DNA, is highly expressed in AML and predicts poor prognosis. UHRF1 is required for myeloid leukemogenesis by...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Cheng-Long, Chen, Bing-Yi, Li, Zijuan, Yang, Tianbiao, Xu, Chun-Hui, Yang, Ruirui, Yu, Peng-Cheng, Zhao, Jingyao, Liu, Ting, Liu, Na, Shan, Bin, Zhang, Qunling, Song, Junhong, Fei, Ming-Yue, Zong, Li-Juan, Zhang, Jia-Ying, Wu, Ji-Chuan, Chen, Shu-Bei, Wang, Yong, Chang, Binhe, Hou, Dan, Liu, Ping, Jiang, Yilun, Li, Xiya, Chen, Xinchi, Deng, Chu-Han, Ren, Yi-Yi, Wang, Roujia, Jin, Jiacheng, Xue, Kai, Zhang, Ying, Du, Meirong, Shi, Jun, Wu, Ling-Yun, Chang, Chun-Kang, Shen, Shuhong, Chen, Zhu, Chen, Sai-Juan, Liu, Xiaolong, Sun, Xiao-Jian, Zheng, Mingyue, Wang, Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715639/
https://www.ncbi.nlm.nih.gov/pubmed/36302855
http://dx.doi.org/10.1038/s41422-022-00735-6

Ejemplares similares

Ejemplares similares