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Mass cytometry analysis of blood from peanut-sensitized tolerant and clinically allergic infants

IgE-mediated food allergies in infants are a significant health concern, with peanut allergy being of particular interest due to its prevalence and severity. Among individuals who produce peanut-specific IgE some experience no adverse reaction on peanut consumption. This asymptomatic phenotype is kn...

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Autores principales: Tursi, Amanda R., Saba, Nicholas K., Dunham, Diane, Manohar, Monali, Peters, Rachel L., Saffery, Richard, Koplin, Jennifer J., Nadeau, Kari C., Neeland, Melanie R., Andorf, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715645/
https://www.ncbi.nlm.nih.gov/pubmed/36456584
http://dx.doi.org/10.1038/s41597-022-01861-x
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author Tursi, Amanda R.
Saba, Nicholas K.
Dunham, Diane
Manohar, Monali
Peters, Rachel L.
Saffery, Richard
Koplin, Jennifer J.
Nadeau, Kari C.
Neeland, Melanie R.
Andorf, Sandra
author_facet Tursi, Amanda R.
Saba, Nicholas K.
Dunham, Diane
Manohar, Monali
Peters, Rachel L.
Saffery, Richard
Koplin, Jennifer J.
Nadeau, Kari C.
Neeland, Melanie R.
Andorf, Sandra
author_sort Tursi, Amanda R.
collection PubMed
description IgE-mediated food allergies in infants are a significant health concern, with peanut allergy being of particular interest due to its prevalence and severity. Among individuals who produce peanut-specific IgE some experience no adverse reaction on peanut consumption. This asymptomatic phenotype is known as sensitized tolerance. To elucidate the immune environment of peanut sensitized tolerant and clinically allergic one-year-olds, high-dimensional mass cytometry was conducted as part of the HealthNuts study. The resulting data includes peripheral blood mononuclear cells from 36 participants encompassing non-allergic, peanut sensitized with tolerance, and clinically peanut allergic infants. The raw mass cytometry data is described here and freely available for reuse through the Immunology Database and Analysis Portal (ImmPort). Additional allergy information and serum vitamin D levels of the participants were measured and are also included in the data upload. These high-dimensional mass cytometry data, when combined with clinical information, offer a broad immune profile of peanut allergic and sensitized tolerant infants.
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spelling pubmed-97156452022-12-03 Mass cytometry analysis of blood from peanut-sensitized tolerant and clinically allergic infants Tursi, Amanda R. Saba, Nicholas K. Dunham, Diane Manohar, Monali Peters, Rachel L. Saffery, Richard Koplin, Jennifer J. Nadeau, Kari C. Neeland, Melanie R. Andorf, Sandra Sci Data Data Descriptor IgE-mediated food allergies in infants are a significant health concern, with peanut allergy being of particular interest due to its prevalence and severity. Among individuals who produce peanut-specific IgE some experience no adverse reaction on peanut consumption. This asymptomatic phenotype is known as sensitized tolerance. To elucidate the immune environment of peanut sensitized tolerant and clinically allergic one-year-olds, high-dimensional mass cytometry was conducted as part of the HealthNuts study. The resulting data includes peripheral blood mononuclear cells from 36 participants encompassing non-allergic, peanut sensitized with tolerance, and clinically peanut allergic infants. The raw mass cytometry data is described here and freely available for reuse through the Immunology Database and Analysis Portal (ImmPort). Additional allergy information and serum vitamin D levels of the participants were measured and are also included in the data upload. These high-dimensional mass cytometry data, when combined with clinical information, offer a broad immune profile of peanut allergic and sensitized tolerant infants. Nature Publishing Group UK 2022-12-01 /pmc/articles/PMC9715645/ /pubmed/36456584 http://dx.doi.org/10.1038/s41597-022-01861-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Data Descriptor
Tursi, Amanda R.
Saba, Nicholas K.
Dunham, Diane
Manohar, Monali
Peters, Rachel L.
Saffery, Richard
Koplin, Jennifer J.
Nadeau, Kari C.
Neeland, Melanie R.
Andorf, Sandra
Mass cytometry analysis of blood from peanut-sensitized tolerant and clinically allergic infants
title Mass cytometry analysis of blood from peanut-sensitized tolerant and clinically allergic infants
title_full Mass cytometry analysis of blood from peanut-sensitized tolerant and clinically allergic infants
title_fullStr Mass cytometry analysis of blood from peanut-sensitized tolerant and clinically allergic infants
title_full_unstemmed Mass cytometry analysis of blood from peanut-sensitized tolerant and clinically allergic infants
title_short Mass cytometry analysis of blood from peanut-sensitized tolerant and clinically allergic infants
title_sort mass cytometry analysis of blood from peanut-sensitized tolerant and clinically allergic infants
topic Data Descriptor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715645/
https://www.ncbi.nlm.nih.gov/pubmed/36456584
http://dx.doi.org/10.1038/s41597-022-01861-x
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