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Mass cytometry analysis of blood from peanut-sensitized tolerant and clinically allergic infants
IgE-mediated food allergies in infants are a significant health concern, with peanut allergy being of particular interest due to its prevalence and severity. Among individuals who produce peanut-specific IgE some experience no adverse reaction on peanut consumption. This asymptomatic phenotype is kn...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715645/ https://www.ncbi.nlm.nih.gov/pubmed/36456584 http://dx.doi.org/10.1038/s41597-022-01861-x |
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author | Tursi, Amanda R. Saba, Nicholas K. Dunham, Diane Manohar, Monali Peters, Rachel L. Saffery, Richard Koplin, Jennifer J. Nadeau, Kari C. Neeland, Melanie R. Andorf, Sandra |
author_facet | Tursi, Amanda R. Saba, Nicholas K. Dunham, Diane Manohar, Monali Peters, Rachel L. Saffery, Richard Koplin, Jennifer J. Nadeau, Kari C. Neeland, Melanie R. Andorf, Sandra |
author_sort | Tursi, Amanda R. |
collection | PubMed |
description | IgE-mediated food allergies in infants are a significant health concern, with peanut allergy being of particular interest due to its prevalence and severity. Among individuals who produce peanut-specific IgE some experience no adverse reaction on peanut consumption. This asymptomatic phenotype is known as sensitized tolerance. To elucidate the immune environment of peanut sensitized tolerant and clinically allergic one-year-olds, high-dimensional mass cytometry was conducted as part of the HealthNuts study. The resulting data includes peripheral blood mononuclear cells from 36 participants encompassing non-allergic, peanut sensitized with tolerance, and clinically peanut allergic infants. The raw mass cytometry data is described here and freely available for reuse through the Immunology Database and Analysis Portal (ImmPort). Additional allergy information and serum vitamin D levels of the participants were measured and are also included in the data upload. These high-dimensional mass cytometry data, when combined with clinical information, offer a broad immune profile of peanut allergic and sensitized tolerant infants. |
format | Online Article Text |
id | pubmed-9715645 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-97156452022-12-03 Mass cytometry analysis of blood from peanut-sensitized tolerant and clinically allergic infants Tursi, Amanda R. Saba, Nicholas K. Dunham, Diane Manohar, Monali Peters, Rachel L. Saffery, Richard Koplin, Jennifer J. Nadeau, Kari C. Neeland, Melanie R. Andorf, Sandra Sci Data Data Descriptor IgE-mediated food allergies in infants are a significant health concern, with peanut allergy being of particular interest due to its prevalence and severity. Among individuals who produce peanut-specific IgE some experience no adverse reaction on peanut consumption. This asymptomatic phenotype is known as sensitized tolerance. To elucidate the immune environment of peanut sensitized tolerant and clinically allergic one-year-olds, high-dimensional mass cytometry was conducted as part of the HealthNuts study. The resulting data includes peripheral blood mononuclear cells from 36 participants encompassing non-allergic, peanut sensitized with tolerance, and clinically peanut allergic infants. The raw mass cytometry data is described here and freely available for reuse through the Immunology Database and Analysis Portal (ImmPort). Additional allergy information and serum vitamin D levels of the participants were measured and are also included in the data upload. These high-dimensional mass cytometry data, when combined with clinical information, offer a broad immune profile of peanut allergic and sensitized tolerant infants. Nature Publishing Group UK 2022-12-01 /pmc/articles/PMC9715645/ /pubmed/36456584 http://dx.doi.org/10.1038/s41597-022-01861-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Data Descriptor Tursi, Amanda R. Saba, Nicholas K. Dunham, Diane Manohar, Monali Peters, Rachel L. Saffery, Richard Koplin, Jennifer J. Nadeau, Kari C. Neeland, Melanie R. Andorf, Sandra Mass cytometry analysis of blood from peanut-sensitized tolerant and clinically allergic infants |
title | Mass cytometry analysis of blood from peanut-sensitized tolerant and clinically allergic infants |
title_full | Mass cytometry analysis of blood from peanut-sensitized tolerant and clinically allergic infants |
title_fullStr | Mass cytometry analysis of blood from peanut-sensitized tolerant and clinically allergic infants |
title_full_unstemmed | Mass cytometry analysis of blood from peanut-sensitized tolerant and clinically allergic infants |
title_short | Mass cytometry analysis of blood from peanut-sensitized tolerant and clinically allergic infants |
title_sort | mass cytometry analysis of blood from peanut-sensitized tolerant and clinically allergic infants |
topic | Data Descriptor |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715645/ https://www.ncbi.nlm.nih.gov/pubmed/36456584 http://dx.doi.org/10.1038/s41597-022-01861-x |
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