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PPM1D suppresses p53-dependent transactivation and cell death by inhibiting the Integrated Stress Response
The p53 transcription factor is a master regulator of cellular stress responses inhibited by repressors such as MDM2 and the phosphatase PPM1D. Activation of p53 with pharmacological inhibitors of its repressors is being tested in clinical trials for cancer therapy, but efficacy has been limited by...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715646/ https://www.ncbi.nlm.nih.gov/pubmed/36456590 http://dx.doi.org/10.1038/s41467-022-35089-5 |