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Asynchronous calibration of quantitative computed tomography bone mineral density assessment for opportunistic osteoporosis screening: phantom-based validation and parameter influence evaluation
Asynchronous calibration could allow opportunistic screening based on routine CT for early osteoporosis detection. In this phantom study, a bone mineral density (BMD) calibration phantom and multi-energy CT (MECT) phantom were imaged on eight different CT scanners with multiple tube voltages (80–150...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715650/ https://www.ncbi.nlm.nih.gov/pubmed/36456574 http://dx.doi.org/10.1038/s41598-022-24546-2 |
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author | Skornitzke, Stephan Vats, Neha Kopytova, Taisiya Tong, Elizabeth Wai Yee Hofbauer, Tobias Weber, Tim Frederik Rehnitz, Christoph von Stackelberg, Oyunbileg Maier-Hein, Klaus Stiller, Wolfram Biederer, Jürgen Kauczor, Hans-Ulrich Heußel, Claus-Peter Wielpütz, Mark Palm, Viktoria |
author_facet | Skornitzke, Stephan Vats, Neha Kopytova, Taisiya Tong, Elizabeth Wai Yee Hofbauer, Tobias Weber, Tim Frederik Rehnitz, Christoph von Stackelberg, Oyunbileg Maier-Hein, Klaus Stiller, Wolfram Biederer, Jürgen Kauczor, Hans-Ulrich Heußel, Claus-Peter Wielpütz, Mark Palm, Viktoria |
author_sort | Skornitzke, Stephan |
collection | PubMed |
description | Asynchronous calibration could allow opportunistic screening based on routine CT for early osteoporosis detection. In this phantom study, a bone mineral density (BMD) calibration phantom and multi-energy CT (MECT) phantom were imaged on eight different CT scanners with multiple tube voltages (80–150 kV(p)) and image reconstruction settings (e.g. soft/hard kernel). Reference values for asynchronous BMD estimation were calculated from the BMD-phantom and validated with six calcium composite inserts of the MECT-phantom with known ground truth. Relative errors/changes in estimated BMD were calculated and investigated for influence of tube voltage, CT scanner and reconstruction setting. Reference values for 282 acquisitions were determined, resulting in an average relative error between calculated BMD and ground truth of − 9.2% ± 14.0% with a strong correlation (R(2) = 0.99; p < 0.0001). Tube voltage and CT scanner had a significant effect on calculated BMD (p < 0.0001), with relative differences in BMD of 3.8% ± 28.2% when adapting reference values for tube voltage, − 5.6% ± 9.2% for CT scanner and 0.2% ± 0.2% for reconstruction setting, respectively. Differences in BMD were small when using reference values from a different CT scanner of the same model (0.0% ± 1.4%). Asynchronous phantom-based calibration is feasible for opportunistic BMD assessment based on CT images with reference values adapted for tube voltage and CT scanner model. |
format | Online Article Text |
id | pubmed-9715650 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-97156502022-12-03 Asynchronous calibration of quantitative computed tomography bone mineral density assessment for opportunistic osteoporosis screening: phantom-based validation and parameter influence evaluation Skornitzke, Stephan Vats, Neha Kopytova, Taisiya Tong, Elizabeth Wai Yee Hofbauer, Tobias Weber, Tim Frederik Rehnitz, Christoph von Stackelberg, Oyunbileg Maier-Hein, Klaus Stiller, Wolfram Biederer, Jürgen Kauczor, Hans-Ulrich Heußel, Claus-Peter Wielpütz, Mark Palm, Viktoria Sci Rep Article Asynchronous calibration could allow opportunistic screening based on routine CT for early osteoporosis detection. In this phantom study, a bone mineral density (BMD) calibration phantom and multi-energy CT (MECT) phantom were imaged on eight different CT scanners with multiple tube voltages (80–150 kV(p)) and image reconstruction settings (e.g. soft/hard kernel). Reference values for asynchronous BMD estimation were calculated from the BMD-phantom and validated with six calcium composite inserts of the MECT-phantom with known ground truth. Relative errors/changes in estimated BMD were calculated and investigated for influence of tube voltage, CT scanner and reconstruction setting. Reference values for 282 acquisitions were determined, resulting in an average relative error between calculated BMD and ground truth of − 9.2% ± 14.0% with a strong correlation (R(2) = 0.99; p < 0.0001). Tube voltage and CT scanner had a significant effect on calculated BMD (p < 0.0001), with relative differences in BMD of 3.8% ± 28.2% when adapting reference values for tube voltage, − 5.6% ± 9.2% for CT scanner and 0.2% ± 0.2% for reconstruction setting, respectively. Differences in BMD were small when using reference values from a different CT scanner of the same model (0.0% ± 1.4%). Asynchronous phantom-based calibration is feasible for opportunistic BMD assessment based on CT images with reference values adapted for tube voltage and CT scanner model. Nature Publishing Group UK 2022-12-01 /pmc/articles/PMC9715650/ /pubmed/36456574 http://dx.doi.org/10.1038/s41598-022-24546-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Skornitzke, Stephan Vats, Neha Kopytova, Taisiya Tong, Elizabeth Wai Yee Hofbauer, Tobias Weber, Tim Frederik Rehnitz, Christoph von Stackelberg, Oyunbileg Maier-Hein, Klaus Stiller, Wolfram Biederer, Jürgen Kauczor, Hans-Ulrich Heußel, Claus-Peter Wielpütz, Mark Palm, Viktoria Asynchronous calibration of quantitative computed tomography bone mineral density assessment for opportunistic osteoporosis screening: phantom-based validation and parameter influence evaluation |
title | Asynchronous calibration of quantitative computed tomography bone mineral density assessment for opportunistic osteoporosis screening: phantom-based validation and parameter influence evaluation |
title_full | Asynchronous calibration of quantitative computed tomography bone mineral density assessment for opportunistic osteoporosis screening: phantom-based validation and parameter influence evaluation |
title_fullStr | Asynchronous calibration of quantitative computed tomography bone mineral density assessment for opportunistic osteoporosis screening: phantom-based validation and parameter influence evaluation |
title_full_unstemmed | Asynchronous calibration of quantitative computed tomography bone mineral density assessment for opportunistic osteoporosis screening: phantom-based validation and parameter influence evaluation |
title_short | Asynchronous calibration of quantitative computed tomography bone mineral density assessment for opportunistic osteoporosis screening: phantom-based validation and parameter influence evaluation |
title_sort | asynchronous calibration of quantitative computed tomography bone mineral density assessment for opportunistic osteoporosis screening: phantom-based validation and parameter influence evaluation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715650/ https://www.ncbi.nlm.nih.gov/pubmed/36456574 http://dx.doi.org/10.1038/s41598-022-24546-2 |
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