Pan-cancer landscape of AID-related mutations, composite mutations, and their potential role in the ICI response

Activation-induced cytidine deaminase, AICDA or AID, is a driver of somatic hypermutation and class-switch recombination in immunoglobulins. In addition, this deaminase belonging to the APOBEC family may have off-target effects genome-wide, but its effects at pan-cancer level are not well elucidated...

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Detalles Bibliográficos
Autores principales: Hernández-Verdin, Isaias, Akdemir, Kadir C., Ramazzotti, Daniele, Caravagna, Giulio, Labreche, Karim, Mokhtari, Karima, Hoang-Xuan, Khê, Peyre, Matthieu, Bielle, Franck, Touat, Mehdi, Idbaih, Ahmed, Duval, Alex, Sanson, Marc, Alentorn, Agustí
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715662/
https://www.ncbi.nlm.nih.gov/pubmed/36456685
http://dx.doi.org/10.1038/s41698-022-00331-2

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