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Dietary glucosamine overcomes the defects in αβ-T cell ontogeny caused by the loss of de novo hexosamine biosynthesis

T cell development requires the coordinated rearrangement of T cell receptor (TCR) gene segments and the expression of either αβ or γδ TCR. However, whether and how de novo synthesis of nutrients contributes to thymocyte commitment to either lineage remains unclear. Here, we find that T cell-specifi...

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Detalles Bibliográficos
Autores principales:	Werlen, Guy, Li, Mei-Ling, Tottone, Luca, da Silva-Diz, Victoria, Su, Xiaoyang, Herranz, Daniel, Jacinto, Estela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715696/ https://www.ncbi.nlm.nih.gov/pubmed/36456551 http://dx.doi.org/10.1038/s41467-022-35014-w

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