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Enhancement of DNA hypomethylation alterations by gastric and bile acids promotes chromosomal instability in Barrett’s epithelial cell line

Gastric and bile acid reflux leads to chronic inflammation, resulting in methylation alterations in Barrett’s esophagus (BE) together with chromosomal instability (CIN). We investigated DNA hypomethylation following acid exposure and confirmed its significance in BE-related carcinogenesis by inducin...

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Detalles Bibliográficos
Autores principales:	Abe, Iku, Suzuki, Koichi, Kimura, Yasuaki, Tamaki, Sawako, Endo, Yuhei, Ichida, Kosuke, Muto, Yuta, Watanabe, Fumiaki, Saito, Masaaki, Konishi, Fumio, Rikiyama, Toshiki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715700/ https://www.ncbi.nlm.nih.gov/pubmed/36456615 http://dx.doi.org/10.1038/s41598-022-25279-y

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