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“In medio stat virtus”: Insights into hybrid E/M phenotype attitudes

Epithelial-mesenchymal plasticity (EMP) refers to the ability of cells to dynamically interconvert between epithelial (E) and mesenchymal (M) phenotypes, thus generating an array of hybrid E/M intermediates with mixed E and M features. Recent findings have demonstrated how these hybrid E/M rather th...

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Autores principales: Canciello, Angelo, Cerveró-Varona, Adrián, Peserico, Alessia, Mauro, Annunziata, Russo, Valentina, Morrione, Andrea, Giordano, Antonio, Barboni, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715750/
https://www.ncbi.nlm.nih.gov/pubmed/36467417
http://dx.doi.org/10.3389/fcell.2022.1038841
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author Canciello, Angelo
Cerveró-Varona, Adrián
Peserico, Alessia
Mauro, Annunziata
Russo, Valentina
Morrione, Andrea
Giordano, Antonio
Barboni, Barbara
author_facet Canciello, Angelo
Cerveró-Varona, Adrián
Peserico, Alessia
Mauro, Annunziata
Russo, Valentina
Morrione, Andrea
Giordano, Antonio
Barboni, Barbara
author_sort Canciello, Angelo
collection PubMed
description Epithelial-mesenchymal plasticity (EMP) refers to the ability of cells to dynamically interconvert between epithelial (E) and mesenchymal (M) phenotypes, thus generating an array of hybrid E/M intermediates with mixed E and M features. Recent findings have demonstrated how these hybrid E/M rather than fully M cells play key roles in most of physiological and pathological processes involving EMT. To this regard, the onset of hybrid E/M state coincides with the highest stemness gene expression and is involved in differentiation of either normal and cancer stem cells. Moreover, hybrid E/M cells are responsible for wound healing and create a favorable immunosuppressive environment for tissue regeneration. Nevertheless, hybrid state is responsible of metastatic process and of the increasing of survival, apoptosis and therapy resistance in cancer cells. The present review aims to describe the main features and the emerging concepts regulating EMP and the formation of E/M hybrid intermediates by describing differences and similarities between cancer and normal hybrid stem cells. In particular, the comprehension of hybrid E/M cells biology will surely advance our understanding of their features and how they could be exploited to improve tissue regeneration and repair.
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spelling pubmed-97157502022-12-03 “In medio stat virtus”: Insights into hybrid E/M phenotype attitudes Canciello, Angelo Cerveró-Varona, Adrián Peserico, Alessia Mauro, Annunziata Russo, Valentina Morrione, Andrea Giordano, Antonio Barboni, Barbara Front Cell Dev Biol Cell and Developmental Biology Epithelial-mesenchymal plasticity (EMP) refers to the ability of cells to dynamically interconvert between epithelial (E) and mesenchymal (M) phenotypes, thus generating an array of hybrid E/M intermediates with mixed E and M features. Recent findings have demonstrated how these hybrid E/M rather than fully M cells play key roles in most of physiological and pathological processes involving EMT. To this regard, the onset of hybrid E/M state coincides with the highest stemness gene expression and is involved in differentiation of either normal and cancer stem cells. Moreover, hybrid E/M cells are responsible for wound healing and create a favorable immunosuppressive environment for tissue regeneration. Nevertheless, hybrid state is responsible of metastatic process and of the increasing of survival, apoptosis and therapy resistance in cancer cells. The present review aims to describe the main features and the emerging concepts regulating EMP and the formation of E/M hybrid intermediates by describing differences and similarities between cancer and normal hybrid stem cells. In particular, the comprehension of hybrid E/M cells biology will surely advance our understanding of their features and how they could be exploited to improve tissue regeneration and repair. Frontiers Media S.A. 2022-11-18 /pmc/articles/PMC9715750/ /pubmed/36467417 http://dx.doi.org/10.3389/fcell.2022.1038841 Text en Copyright © 2022 Canciello, Cerveró-Varona, Peserico, Mauro, Russo, Morrione, Giordano and Barboni. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Canciello, Angelo
Cerveró-Varona, Adrián
Peserico, Alessia
Mauro, Annunziata
Russo, Valentina
Morrione, Andrea
Giordano, Antonio
Barboni, Barbara
“In medio stat virtus”: Insights into hybrid E/M phenotype attitudes
title “In medio stat virtus”: Insights into hybrid E/M phenotype attitudes
title_full “In medio stat virtus”: Insights into hybrid E/M phenotype attitudes
title_fullStr “In medio stat virtus”: Insights into hybrid E/M phenotype attitudes
title_full_unstemmed “In medio stat virtus”: Insights into hybrid E/M phenotype attitudes
title_short “In medio stat virtus”: Insights into hybrid E/M phenotype attitudes
title_sort “in medio stat virtus”: insights into hybrid e/m phenotype attitudes
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715750/
https://www.ncbi.nlm.nih.gov/pubmed/36467417
http://dx.doi.org/10.3389/fcell.2022.1038841
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