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Development and validation of nodal staging score in pN0 patients with esophageal squamous cell carcinoma: A population study from the SEER database and a single‐institution cohort
BACKGROUND: Patients with esophageal squamous cell carcinoma (ESCC) with lymph node metastasis may be misclassified as pN0 due to an insufficient number of lymph nodes examined (LNE). The purpose of this study was to confirm that patients with ESCC are indeed pN0 and to propose an adequate number fo...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons Australia, Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715890/ https://www.ncbi.nlm.nih.gov/pubmed/36221304 http://dx.doi.org/10.1111/1759-7714.14670 |
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author | Wang, Haitong Yang, Yueyang zhu, Kai Zhu, Ningning Gong, Lei Zhang, Hongdian Ma, Mingquan Ren, Peng Qiao, Yufeng Liu, Xiangming Tang, Peng Yu, Zhentao |
author_facet | Wang, Haitong Yang, Yueyang zhu, Kai Zhu, Ningning Gong, Lei Zhang, Hongdian Ma, Mingquan Ren, Peng Qiao, Yufeng Liu, Xiangming Tang, Peng Yu, Zhentao |
author_sort | Wang, Haitong |
collection | PubMed |
description | BACKGROUND: Patients with esophageal squamous cell carcinoma (ESCC) with lymph node metastasis may be misclassified as pN0 due to an insufficient number of lymph nodes examined (LNE). The purpose of this study was to confirm that patients with ESCC are indeed pN0 and to propose an adequate number for the correct nodal stage using the nodal staging score (NSS) developed by the beta‐binomial model. METHODS: A total of 1249 patients from the Surveillance, Epidemiology, and End Results (SEER) database between 2000 and 2017, and 1404 patients diagnosed with ESCC in our database between 2005 and 2018 were included. The NSS was developed to assess the probability of pN0 status based on both databases. The effectiveness of NSS was verified using survival analysis, including Kaplan–Meier curves and Cox models. RESULTS: Many patients were misclassified as pN0 based on our algorithm due to insufficient LNE. As the number of LNE increased, false‐negative findings dropped; accordingly, the NSS increased. In addition, NSS was an independent prognostic indicator for pN0 in patients with ESCC in the SEER database (hazard ratio [HR] 0.182, 95% confidence interval [CI] 0.046–0.730, p = 0.016) and our database (HR 0.215, 95% CI 0.055–0.842, p = 0.027). A certain number of nodes must be examined to achieve 90% of the NSS. CONCLUSIONS: NSS could determine the probability of true pN0 status for patients, and it was sufficient in predicting survival and obtaining adequate numbers for lymphadenectomy. |
format | Online Article Text |
id | pubmed-9715890 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley & Sons Australia, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-97158902022-12-05 Development and validation of nodal staging score in pN0 patients with esophageal squamous cell carcinoma: A population study from the SEER database and a single‐institution cohort Wang, Haitong Yang, Yueyang zhu, Kai Zhu, Ningning Gong, Lei Zhang, Hongdian Ma, Mingquan Ren, Peng Qiao, Yufeng Liu, Xiangming Tang, Peng Yu, Zhentao Thorac Cancer Original Articles BACKGROUND: Patients with esophageal squamous cell carcinoma (ESCC) with lymph node metastasis may be misclassified as pN0 due to an insufficient number of lymph nodes examined (LNE). The purpose of this study was to confirm that patients with ESCC are indeed pN0 and to propose an adequate number for the correct nodal stage using the nodal staging score (NSS) developed by the beta‐binomial model. METHODS: A total of 1249 patients from the Surveillance, Epidemiology, and End Results (SEER) database between 2000 and 2017, and 1404 patients diagnosed with ESCC in our database between 2005 and 2018 were included. The NSS was developed to assess the probability of pN0 status based on both databases. The effectiveness of NSS was verified using survival analysis, including Kaplan–Meier curves and Cox models. RESULTS: Many patients were misclassified as pN0 based on our algorithm due to insufficient LNE. As the number of LNE increased, false‐negative findings dropped; accordingly, the NSS increased. In addition, NSS was an independent prognostic indicator for pN0 in patients with ESCC in the SEER database (hazard ratio [HR] 0.182, 95% confidence interval [CI] 0.046–0.730, p = 0.016) and our database (HR 0.215, 95% CI 0.055–0.842, p = 0.027). A certain number of nodes must be examined to achieve 90% of the NSS. CONCLUSIONS: NSS could determine the probability of true pN0 status for patients, and it was sufficient in predicting survival and obtaining adequate numbers for lymphadenectomy. John Wiley & Sons Australia, Ltd 2022-10-11 2022-12 /pmc/articles/PMC9715890/ /pubmed/36221304 http://dx.doi.org/10.1111/1759-7714.14670 Text en © 2022 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Wang, Haitong Yang, Yueyang zhu, Kai Zhu, Ningning Gong, Lei Zhang, Hongdian Ma, Mingquan Ren, Peng Qiao, Yufeng Liu, Xiangming Tang, Peng Yu, Zhentao Development and validation of nodal staging score in pN0 patients with esophageal squamous cell carcinoma: A population study from the SEER database and a single‐institution cohort |
title | Development and validation of nodal staging score in pN0 patients with esophageal squamous cell carcinoma: A population study from the SEER database and a single‐institution cohort |
title_full | Development and validation of nodal staging score in pN0 patients with esophageal squamous cell carcinoma: A population study from the SEER database and a single‐institution cohort |
title_fullStr | Development and validation of nodal staging score in pN0 patients with esophageal squamous cell carcinoma: A population study from the SEER database and a single‐institution cohort |
title_full_unstemmed | Development and validation of nodal staging score in pN0 patients with esophageal squamous cell carcinoma: A population study from the SEER database and a single‐institution cohort |
title_short | Development and validation of nodal staging score in pN0 patients with esophageal squamous cell carcinoma: A population study from the SEER database and a single‐institution cohort |
title_sort | development and validation of nodal staging score in pn0 patients with esophageal squamous cell carcinoma: a population study from the seer database and a single‐institution cohort |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715890/ https://www.ncbi.nlm.nih.gov/pubmed/36221304 http://dx.doi.org/10.1111/1759-7714.14670 |
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