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Myocardial fibrosis in congenital heart disease
Myocardial fibrosis resulting from the excessive deposition of collagen fibers through the myocardium is a common histopathologic finding in a wide range of cardiovascular diseases, including congenital anomalies. Interstitial fibrosis has been identified as a major cause of myocardial dysfunction s...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715985/ https://www.ncbi.nlm.nih.gov/pubmed/36467466 http://dx.doi.org/10.3389/fped.2022.965204 |
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author | Gordon, Blanca González-Fernández, Víctor Dos-Subirà, Laura |
author_facet | Gordon, Blanca González-Fernández, Víctor Dos-Subirà, Laura |
author_sort | Gordon, Blanca |
collection | PubMed |
description | Myocardial fibrosis resulting from the excessive deposition of collagen fibers through the myocardium is a common histopathologic finding in a wide range of cardiovascular diseases, including congenital anomalies. Interstitial fibrosis has been identified as a major cause of myocardial dysfunction since it distorts the normal architecture of the myocardium and impairs the biological function and properties of the interstitium. This review summarizes current knowledge on the mechanisms and detrimental consequences of myocardial fibrosis in heart failure and arrhythmias, discusses the usefulness of available imaging techniques and circulating biomarkers to assess this entity and reviews the current body of evidence regarding myocardial fibrosis in the different subsets of congenital heart diseases with implications in research and treatment. |
format | Online Article Text |
id | pubmed-9715985 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97159852022-12-03 Myocardial fibrosis in congenital heart disease Gordon, Blanca González-Fernández, Víctor Dos-Subirà, Laura Front Pediatr Pediatrics Myocardial fibrosis resulting from the excessive deposition of collagen fibers through the myocardium is a common histopathologic finding in a wide range of cardiovascular diseases, including congenital anomalies. Interstitial fibrosis has been identified as a major cause of myocardial dysfunction since it distorts the normal architecture of the myocardium and impairs the biological function and properties of the interstitium. This review summarizes current knowledge on the mechanisms and detrimental consequences of myocardial fibrosis in heart failure and arrhythmias, discusses the usefulness of available imaging techniques and circulating biomarkers to assess this entity and reviews the current body of evidence regarding myocardial fibrosis in the different subsets of congenital heart diseases with implications in research and treatment. Frontiers Media S.A. 2022-11-18 /pmc/articles/PMC9715985/ /pubmed/36467466 http://dx.doi.org/10.3389/fped.2022.965204 Text en © 2022 Gordon, González-Fernández and Dos-Subirà. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Gordon, Blanca González-Fernández, Víctor Dos-Subirà, Laura Myocardial fibrosis in congenital heart disease |
title | Myocardial fibrosis in congenital heart disease |
title_full | Myocardial fibrosis in congenital heart disease |
title_fullStr | Myocardial fibrosis in congenital heart disease |
title_full_unstemmed | Myocardial fibrosis in congenital heart disease |
title_short | Myocardial fibrosis in congenital heart disease |
title_sort | myocardial fibrosis in congenital heart disease |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715985/ https://www.ncbi.nlm.nih.gov/pubmed/36467466 http://dx.doi.org/10.3389/fped.2022.965204 |
work_keys_str_mv | AT gordonblanca myocardialfibrosisincongenitalheartdisease AT gonzalezfernandezvictor myocardialfibrosisincongenitalheartdisease AT dossubiralaura myocardialfibrosisincongenitalheartdisease |