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Hepatic dysfunctions in COVID-19 patients infected by the omicron variant of SARS-CoV-2
BACKGROUND: Presently, the omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) dominates amid the coronavirus disease 2019 (COVID-19) pandemic, but its clinical characteristics with intrinsic severity and organ tropism remain understudied. METHODS: We reported 1,001 mild...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716022/ https://www.ncbi.nlm.nih.gov/pubmed/36466505 http://dx.doi.org/10.3389/fpubh.2022.1049006 |
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author | Zhang, Jianguo Zhao, Daguo Hu, Jianhui Huang, Xing Gu, Qingqing Tao, Zhimin |
author_facet | Zhang, Jianguo Zhao, Daguo Hu, Jianhui Huang, Xing Gu, Qingqing Tao, Zhimin |
author_sort | Zhang, Jianguo |
collection | PubMed |
description | BACKGROUND: Presently, the omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) dominates amid the coronavirus disease 2019 (COVID-19) pandemic, but its clinical characteristics with intrinsic severity and organ tropism remain understudied. METHODS: We reported 1,001 mild COVID-19 patients that were infected with the omicron variant of SARS-CoV-2 and hospitalized in China from February to June 2022, including their demographic information, medical/immunization history, clinical symptom, and hematological profile. Patients with one-, two- and three-dose vaccination were compared to assess the vaccine effectiveness. Importantly, liver damage caused by the omicron variant infection was evaluated, in comparison to that caused by the wild-type or the delta variant SARS-CoV-2 infection. RESULTS: For the reported COVID-19 patients infected by the omicron variant of SARS-CoV-2, their median age was 36.0 [interquartile range (IQR): 26.0-50.0] and 49.7% were female. Hypertension, diabetes, and bronchitis were the leading comorbidities, and asymptomatic patients took up a major portion (61.2%). While most hematological parameters revealed the alleviated pathogenicity, full vaccination or booster shot showed effective protection against clinical severity. Furthermore, liver damages caused by viral infection of the omicron variant were largely attenuated when compared to those by infection of the wild-type or the delta variant SARS-CoV-2. CONCLUSIONS: Our results supported that the viremic effect of the omicron variant tended to be modest, while the liver damage caused by this strain became milder than the previous circulating variants. |
format | Online Article Text |
id | pubmed-9716022 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97160222022-12-03 Hepatic dysfunctions in COVID-19 patients infected by the omicron variant of SARS-CoV-2 Zhang, Jianguo Zhao, Daguo Hu, Jianhui Huang, Xing Gu, Qingqing Tao, Zhimin Front Public Health Public Health BACKGROUND: Presently, the omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) dominates amid the coronavirus disease 2019 (COVID-19) pandemic, but its clinical characteristics with intrinsic severity and organ tropism remain understudied. METHODS: We reported 1,001 mild COVID-19 patients that were infected with the omicron variant of SARS-CoV-2 and hospitalized in China from February to June 2022, including their demographic information, medical/immunization history, clinical symptom, and hematological profile. Patients with one-, two- and three-dose vaccination were compared to assess the vaccine effectiveness. Importantly, liver damage caused by the omicron variant infection was evaluated, in comparison to that caused by the wild-type or the delta variant SARS-CoV-2 infection. RESULTS: For the reported COVID-19 patients infected by the omicron variant of SARS-CoV-2, their median age was 36.0 [interquartile range (IQR): 26.0-50.0] and 49.7% were female. Hypertension, diabetes, and bronchitis were the leading comorbidities, and asymptomatic patients took up a major portion (61.2%). While most hematological parameters revealed the alleviated pathogenicity, full vaccination or booster shot showed effective protection against clinical severity. Furthermore, liver damages caused by viral infection of the omicron variant were largely attenuated when compared to those by infection of the wild-type or the delta variant SARS-CoV-2. CONCLUSIONS: Our results supported that the viremic effect of the omicron variant tended to be modest, while the liver damage caused by this strain became milder than the previous circulating variants. Frontiers Media S.A. 2022-11-18 /pmc/articles/PMC9716022/ /pubmed/36466505 http://dx.doi.org/10.3389/fpubh.2022.1049006 Text en Copyright © 2022 Zhang, Zhao, Hu, Huang, Gu and Tao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Public Health Zhang, Jianguo Zhao, Daguo Hu, Jianhui Huang, Xing Gu, Qingqing Tao, Zhimin Hepatic dysfunctions in COVID-19 patients infected by the omicron variant of SARS-CoV-2 |
title | Hepatic dysfunctions in COVID-19 patients infected by the omicron variant of SARS-CoV-2 |
title_full | Hepatic dysfunctions in COVID-19 patients infected by the omicron variant of SARS-CoV-2 |
title_fullStr | Hepatic dysfunctions in COVID-19 patients infected by the omicron variant of SARS-CoV-2 |
title_full_unstemmed | Hepatic dysfunctions in COVID-19 patients infected by the omicron variant of SARS-CoV-2 |
title_short | Hepatic dysfunctions in COVID-19 patients infected by the omicron variant of SARS-CoV-2 |
title_sort | hepatic dysfunctions in covid-19 patients infected by the omicron variant of sars-cov-2 |
topic | Public Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716022/ https://www.ncbi.nlm.nih.gov/pubmed/36466505 http://dx.doi.org/10.3389/fpubh.2022.1049006 |
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