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Serological investigation of plague and brucellosis infection in Marmota himalayana plague foci in the Altun Mountains on the Qinghai-Tibet Plateau

The Altun Mountains are among the most active regions of Marmota himalayana plague foci of the Qinghai-Tibet Plateau where animal plague is prevalent, whereas only three human cases have been found since 1960. Animal husbandry is the main income for the local economy; brucellosis appears sometimes i...

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Autores principales: Qin, Shuai, Liang, Junrong, Tang, Deming, Chen, Yuhuang, Duan, Ran, Lu, Xinmin, Bukai, Asaiti, Zheng, Xiaojin, Lv, Dongyue, He, Zhaokai, Wu, Weiwei, Han, Haonan, Jing, Huaiqi, Wang, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716105/
https://www.ncbi.nlm.nih.gov/pubmed/36466443
http://dx.doi.org/10.3389/fpubh.2022.990218
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author Qin, Shuai
Liang, Junrong
Tang, Deming
Chen, Yuhuang
Duan, Ran
Lu, Xinmin
Bukai, Asaiti
Zheng, Xiaojin
Lv, Dongyue
He, Zhaokai
Wu, Weiwei
Han, Haonan
Jing, Huaiqi
Wang, Xin
author_facet Qin, Shuai
Liang, Junrong
Tang, Deming
Chen, Yuhuang
Duan, Ran
Lu, Xinmin
Bukai, Asaiti
Zheng, Xiaojin
Lv, Dongyue
He, Zhaokai
Wu, Weiwei
Han, Haonan
Jing, Huaiqi
Wang, Xin
author_sort Qin, Shuai
collection PubMed
description The Altun Mountains are among the most active regions of Marmota himalayana plague foci of the Qinghai-Tibet Plateau where animal plague is prevalent, whereas only three human cases have been found since 1960. Animal husbandry is the main income for the local economy; brucellosis appears sometimes in animals and less often in humans. In this study, a retrospective investigation of plague and brucellosis seroprevalence among humans and animals was conducted to improve prevention and control measures for the two diseases. Animal and human sera were collected for routine surveillance from 2018 to 2021 and screened for plague and brucellosis. Yersinia pestis F1 antibody was preliminarily screened by the colloidal gold method at the monitoring site to identify previous infections with positive serology. Previous plague infection was found in 3.2% (14/432) of the studied human population having close contact with livestock, which indicates evidence of exposure to the Yersinia antigen (dead or live pathogenic materials) in the Altun Mountains. Seroprevalence of brucellosis was higher in camels (6.2%) and sheepdogs (1.8%) than in other livestock such as cattle and sheep, suggesting a possible transmission route from secondary host animals to humans.
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spelling pubmed-97161052022-12-03 Serological investigation of plague and brucellosis infection in Marmota himalayana plague foci in the Altun Mountains on the Qinghai-Tibet Plateau Qin, Shuai Liang, Junrong Tang, Deming Chen, Yuhuang Duan, Ran Lu, Xinmin Bukai, Asaiti Zheng, Xiaojin Lv, Dongyue He, Zhaokai Wu, Weiwei Han, Haonan Jing, Huaiqi Wang, Xin Front Public Health Public Health The Altun Mountains are among the most active regions of Marmota himalayana plague foci of the Qinghai-Tibet Plateau where animal plague is prevalent, whereas only three human cases have been found since 1960. Animal husbandry is the main income for the local economy; brucellosis appears sometimes in animals and less often in humans. In this study, a retrospective investigation of plague and brucellosis seroprevalence among humans and animals was conducted to improve prevention and control measures for the two diseases. Animal and human sera were collected for routine surveillance from 2018 to 2021 and screened for plague and brucellosis. Yersinia pestis F1 antibody was preliminarily screened by the colloidal gold method at the monitoring site to identify previous infections with positive serology. Previous plague infection was found in 3.2% (14/432) of the studied human population having close contact with livestock, which indicates evidence of exposure to the Yersinia antigen (dead or live pathogenic materials) in the Altun Mountains. Seroprevalence of brucellosis was higher in camels (6.2%) and sheepdogs (1.8%) than in other livestock such as cattle and sheep, suggesting a possible transmission route from secondary host animals to humans. Frontiers Media S.A. 2022-11-18 /pmc/articles/PMC9716105/ /pubmed/36466443 http://dx.doi.org/10.3389/fpubh.2022.990218 Text en Copyright © 2022 Qin, Liang, Tang, Chen, Duan, Lu, Bukai, Zheng, Lv, He, Wu, Han, Jing and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Qin, Shuai
Liang, Junrong
Tang, Deming
Chen, Yuhuang
Duan, Ran
Lu, Xinmin
Bukai, Asaiti
Zheng, Xiaojin
Lv, Dongyue
He, Zhaokai
Wu, Weiwei
Han, Haonan
Jing, Huaiqi
Wang, Xin
Serological investigation of plague and brucellosis infection in Marmota himalayana plague foci in the Altun Mountains on the Qinghai-Tibet Plateau
title Serological investigation of plague and brucellosis infection in Marmota himalayana plague foci in the Altun Mountains on the Qinghai-Tibet Plateau
title_full Serological investigation of plague and brucellosis infection in Marmota himalayana plague foci in the Altun Mountains on the Qinghai-Tibet Plateau
title_fullStr Serological investigation of plague and brucellosis infection in Marmota himalayana plague foci in the Altun Mountains on the Qinghai-Tibet Plateau
title_full_unstemmed Serological investigation of plague and brucellosis infection in Marmota himalayana plague foci in the Altun Mountains on the Qinghai-Tibet Plateau
title_short Serological investigation of plague and brucellosis infection in Marmota himalayana plague foci in the Altun Mountains on the Qinghai-Tibet Plateau
title_sort serological investigation of plague and brucellosis infection in marmota himalayana plague foci in the altun mountains on the qinghai-tibet plateau
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716105/
https://www.ncbi.nlm.nih.gov/pubmed/36466443
http://dx.doi.org/10.3389/fpubh.2022.990218
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