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Expression of MUC1 in different tumours and its clinical significance (Review)

Mucin 1 (MUC1) was the first discovered transmembrane protein of the mucin family; it normally covers epithelial cells of the mucous membrane, providing lubrication and protection. However, aberrant expression of MUC1 is involved in cancer development, invasion and metastasis. It has been reported t...

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Detalles Bibliográficos
Autores principales: Lan, Yue, Ni, Weihua, Tai, Guixiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716114/
https://www.ncbi.nlm.nih.gov/pubmed/36479256
http://dx.doi.org/10.3892/mco.2022.2594
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author Lan, Yue
Ni, Weihua
Tai, Guixiang
author_facet Lan, Yue
Ni, Weihua
Tai, Guixiang
author_sort Lan, Yue
collection PubMed
description Mucin 1 (MUC1) was the first discovered transmembrane protein of the mucin family; it normally covers epithelial cells of the mucous membrane, providing lubrication and protection. However, aberrant expression of MUC1 is involved in cancer development, invasion and metastasis. It has been reported that MUC1 upregulation is highly associated with the progression of different epithelial cancer types, such as lung, liver, pancreatic and breast cancer. Therefore, MUC1 can be used as a specific marker and a target for immunotherapy in clinical applications, and the detection of MUC1 expression levels can be used to diagnose the occurrence, metastasis, prognosis and recurrence of cancer. The present review summarizes the abnormal expression of MUC1 in different tumours and discusses its clinical significance, thereby highlighting the potential diagnostic and therapeutic significance of MUC1 in cancer.
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spelling pubmed-97161142022-12-06 Expression of MUC1 in different tumours and its clinical significance (Review) Lan, Yue Ni, Weihua Tai, Guixiang Mol Clin Oncol Review Mucin 1 (MUC1) was the first discovered transmembrane protein of the mucin family; it normally covers epithelial cells of the mucous membrane, providing lubrication and protection. However, aberrant expression of MUC1 is involved in cancer development, invasion and metastasis. It has been reported that MUC1 upregulation is highly associated with the progression of different epithelial cancer types, such as lung, liver, pancreatic and breast cancer. Therefore, MUC1 can be used as a specific marker and a target for immunotherapy in clinical applications, and the detection of MUC1 expression levels can be used to diagnose the occurrence, metastasis, prognosis and recurrence of cancer. The present review summarizes the abnormal expression of MUC1 in different tumours and discusses its clinical significance, thereby highlighting the potential diagnostic and therapeutic significance of MUC1 in cancer. D.A. Spandidos 2022-11-01 /pmc/articles/PMC9716114/ /pubmed/36479256 http://dx.doi.org/10.3892/mco.2022.2594 Text en Copyright: © Lan et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Lan, Yue
Ni, Weihua
Tai, Guixiang
Expression of MUC1 in different tumours and its clinical significance (Review)
title Expression of MUC1 in different tumours and its clinical significance (Review)
title_full Expression of MUC1 in different tumours and its clinical significance (Review)
title_fullStr Expression of MUC1 in different tumours and its clinical significance (Review)
title_full_unstemmed Expression of MUC1 in different tumours and its clinical significance (Review)
title_short Expression of MUC1 in different tumours and its clinical significance (Review)
title_sort expression of muc1 in different tumours and its clinical significance (review)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716114/
https://www.ncbi.nlm.nih.gov/pubmed/36479256
http://dx.doi.org/10.3892/mco.2022.2594
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