Functional dynamics of SARS-CoV-2 3C-like protease as a member of clan PA

SARS-CoV-2 3C-like protease (3CL(pro)), a potential therapeutic target for COVID-19, consists of a chymotrypsin fold and a C-terminal α-helical domain (domain III), the latter of which mediates dimerization required for catalytic activation. To gain further understanding of the functional dynamics o...

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Detalles Bibliográficos
Autores principales: Kidera, Akinori, Moritsugu, Kei, Ekimoto, Toru, Ikeguchi, Mitsunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716165/
https://www.ncbi.nlm.nih.gov/pubmed/36474932
http://dx.doi.org/10.1007/s12551-022-01020-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716165/
https://www.ncbi.nlm.nih.gov/pubmed/36474932
http://dx.doi.org/10.1007/s12551-022-01020-x

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