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Response to BRAF-targeted Therapy Is Enhanced by Cotargeting VEGFRs or WNT/β-Catenin Signaling in BRAF-mutant Colorectal Cancer Models

The fact that 10% of colorectal cancer tumors harbor BRAF V600E mutations suggested targeting BRAF as a potential therapy. However, BRAF inhibitors have only limited single-agent efficacy in this context. The potential for combination therapy has been shown by the BEACON trial where targeting the EG...

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Detalles Bibliográficos
Autores principales:	Tran, Khanh B., Kolekar, Sharada, Wang, Qian, Shih, Jen-Hsing, Buchanan, Christina M., Deva, Sanjeev, Shepherd, Peter R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2022
Materias:	Small Molecule Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716247/ https://www.ncbi.nlm.nih.gov/pubmed/36198029 http://dx.doi.org/10.1158/1535-7163.MCT-21-0941

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