Distinct Tumor Necrosis Factor Alpha Receptors Dictate Stem Cell Fitness versus Lineage Output in Dnmt3a-Mutant Clonal Hematopoiesis

Clonal hematopoiesis resulting from the enhanced fitness of mutant hematopoietic stem cells (HSC) associates with both favorable and unfavorable health outcomes related to the types of mature mutant blood cells produced, but how this lineage output is regulated is unclear. Using a mouse model of a c...

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Detalles Bibliográficos
Autores principales: SanMiguel, Jennifer M., Eudy, Elizabeth, Loberg, Matthew A., Young, Kira A., Mistry, Jayna J., Mujica, Kristina D., Schwartz, Logan S., Stearns, Timothy M., Challen, Grant A., Trowbridge, Jennifer J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Briefs
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716249/
https://www.ncbi.nlm.nih.gov/pubmed/36169447
http://dx.doi.org/10.1158/2159-8290.CD-22-0086

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