Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors

Cytotoxic T lymphocytes (CTL) are antigen-specific effector cells with the ability to eradicate cancer cells in a contact-dependent manner. Metabolic perturbation compromises the CTL effector response in tumor subregions, resulting in failed cancer cell elimination despite the infiltration of tumor-...

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Detalles Bibliográficos
Autores principales: Slaats, Jeroen, Wagena, Esther, Smits, Daan, Berends, Annemarie A., Peters, Ella, Bakker, Gert-Jan, van Erp, Merijn, Weigelin, Bettina, Adema, Gosse J., Friedl, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716258/
https://www.ncbi.nlm.nih.gov/pubmed/36162129
http://dx.doi.org/10.1158/2326-6066.CIR-22-0113

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