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Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis
Thyroid hormones (THs) play a major role regulating energy balance and brown adipose tissue (BAT) thermogenesis, as well as body temperature, as shown in hyperthyroid patients. However, the current landscape of preclinical thyroid hormone models is complex. For example, while rats become catabolic a...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716276/ https://www.ncbi.nlm.nih.gov/pubmed/36467699 http://dx.doi.org/10.3389/fphys.2022.1017381 |
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author | Rial-Pensado, Eva Rivas-Limeres, Verónica Grijota-Martínez, Carmen Rodríguez-Díaz, Amanda Capelli, Valentina Barca-Mayo, Olga Nogueiras, Rubén Mittag, Jens Diéguez, Carlos López, Miguel |
author_facet | Rial-Pensado, Eva Rivas-Limeres, Verónica Grijota-Martínez, Carmen Rodríguez-Díaz, Amanda Capelli, Valentina Barca-Mayo, Olga Nogueiras, Rubén Mittag, Jens Diéguez, Carlos López, Miguel |
author_sort | Rial-Pensado, Eva |
collection | PubMed |
description | Thyroid hormones (THs) play a major role regulating energy balance and brown adipose tissue (BAT) thermogenesis, as well as body temperature, as shown in hyperthyroid patients. However, the current landscape of preclinical thyroid hormone models is complex. For example, while rats become catabolic after TH administration, mice gain weight; so, these differences in species need to be analyzed in detail and specially whether temperature could be a factor. Here, we aimed to investigate the effect of environmental temperature on those actions. Rats were subcutaneously treated with L-thyroxine (T4) or stereotaxically within the ventromedial nucleus of the hypothalamus (VMH) with triiodothyronine (T3) and housed at 23°C, 4°C or 30°C; energy balance, BAT thermogenesis and AMP-activated protein kinase (AMPK) in the VMH were analyzed. Our data showed that the effect of both systemic T4 of central T3 on energy balance and BAT thermogenesis was dependent upon environmental temperature. This evidence is of interest in the design of experimental settings highlighting the species-specific metabolic actions of THs, and in understanding its physiological role in the adaptation to temperature. |
format | Online Article Text |
id | pubmed-9716276 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97162762022-12-03 Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis Rial-Pensado, Eva Rivas-Limeres, Verónica Grijota-Martínez, Carmen Rodríguez-Díaz, Amanda Capelli, Valentina Barca-Mayo, Olga Nogueiras, Rubén Mittag, Jens Diéguez, Carlos López, Miguel Front Physiol Physiology Thyroid hormones (THs) play a major role regulating energy balance and brown adipose tissue (BAT) thermogenesis, as well as body temperature, as shown in hyperthyroid patients. However, the current landscape of preclinical thyroid hormone models is complex. For example, while rats become catabolic after TH administration, mice gain weight; so, these differences in species need to be analyzed in detail and specially whether temperature could be a factor. Here, we aimed to investigate the effect of environmental temperature on those actions. Rats were subcutaneously treated with L-thyroxine (T4) or stereotaxically within the ventromedial nucleus of the hypothalamus (VMH) with triiodothyronine (T3) and housed at 23°C, 4°C or 30°C; energy balance, BAT thermogenesis and AMP-activated protein kinase (AMPK) in the VMH were analyzed. Our data showed that the effect of both systemic T4 of central T3 on energy balance and BAT thermogenesis was dependent upon environmental temperature. This evidence is of interest in the design of experimental settings highlighting the species-specific metabolic actions of THs, and in understanding its physiological role in the adaptation to temperature. Frontiers Media S.A. 2022-11-18 /pmc/articles/PMC9716276/ /pubmed/36467699 http://dx.doi.org/10.3389/fphys.2022.1017381 Text en Copyright © 2022 Rial-Pensado, Rivas-Limeres, Grijota-Martínez, Rodríguez-Díaz, Capelli, Barca-Mayo, Nogueiras, Mittag, Diéguez and López. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Rial-Pensado, Eva Rivas-Limeres, Verónica Grijota-Martínez, Carmen Rodríguez-Díaz, Amanda Capelli, Valentina Barca-Mayo, Olga Nogueiras, Rubén Mittag, Jens Diéguez, Carlos López, Miguel Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis |
title | Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis |
title_full | Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis |
title_fullStr | Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis |
title_full_unstemmed | Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis |
title_short | Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis |
title_sort | temperature modulates systemic and central actions of thyroid hormones on bat thermogenesis |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716276/ https://www.ncbi.nlm.nih.gov/pubmed/36467699 http://dx.doi.org/10.3389/fphys.2022.1017381 |
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