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The effects of FTO gene rs9939609 polymorphism on the association between breast cancer and dietary intake
Breast cancer (BC) is the leading cause of cancer‐related deaths in females worldwide and is related to genetic and environmental factors. Dietary components may strongly influence the risk of BC. A possible association was also reported between the fat mass and obesity‐associated (FTO) single‐nucle...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716323/ https://www.ncbi.nlm.nih.gov/pubmed/36403211 http://dx.doi.org/10.1111/jcmm.17595 |
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author | Doaei, Saeid Abdollahi, Sepideh Mohseni, Golsa Khalatbari Gholamalizadeh, Maryam Akbari, Mohammad Esmail Poorhosseini, Seyed Mohammad Bagheri, Seyedeh Elaheh Ghafouri‐Fard, Soudeh Tabesh, Ghasem Azizi Moslem, Alireza Hasanpour Ardekanizadeh, Naeemeh Omidi, Saeed Hekmatdoost, Azita Alam Rajabi, Mahdi Mosavi Jarrahi, Seyed Alireza Goodarzi, Mark O. |
author_facet | Doaei, Saeid Abdollahi, Sepideh Mohseni, Golsa Khalatbari Gholamalizadeh, Maryam Akbari, Mohammad Esmail Poorhosseini, Seyed Mohammad Bagheri, Seyedeh Elaheh Ghafouri‐Fard, Soudeh Tabesh, Ghasem Azizi Moslem, Alireza Hasanpour Ardekanizadeh, Naeemeh Omidi, Saeed Hekmatdoost, Azita Alam Rajabi, Mahdi Mosavi Jarrahi, Seyed Alireza Goodarzi, Mark O. |
author_sort | Doaei, Saeid |
collection | PubMed |
description | Breast cancer (BC) is the leading cause of cancer‐related deaths in females worldwide and is related to genetic and environmental factors. Dietary components may strongly influence the risk of BC. A possible association was also reported between the fat mass and obesity‐associated (FTO) single‐nucleotide polymorphisms (SNPs) and BC. This study aimed to investigate the impact of FTO rs9939609 polymorphism on the association between BC and dietary intake. This study was conducted on 180 women with BC as the case group and 360 healthy women as the control group. The dietary intakes were assessed by a valid 168‐item food frequency questionnaire (FFQ). The FTO gene was genotyped for rs9939609 polymorphism. After adjusting the confounding variables, there was no significant association between dietary intake and BC in individuals without risk allele. A positive association between dietary intake of omega‐6 fatty acids and BC was found only in individuals with risk allele of FTO gene (OR: 1.31, 95% CI: 1.08–1.60, p: 0.006). FTO gene risk allele may influence the effect of diet on breast cancer risk. Further studies are needed to assess the possible effects of the FTO genotype on the association between BC risk and dietary components. |
format | Online Article Text |
id | pubmed-9716323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97163232022-12-05 The effects of FTO gene rs9939609 polymorphism on the association between breast cancer and dietary intake Doaei, Saeid Abdollahi, Sepideh Mohseni, Golsa Khalatbari Gholamalizadeh, Maryam Akbari, Mohammad Esmail Poorhosseini, Seyed Mohammad Bagheri, Seyedeh Elaheh Ghafouri‐Fard, Soudeh Tabesh, Ghasem Azizi Moslem, Alireza Hasanpour Ardekanizadeh, Naeemeh Omidi, Saeed Hekmatdoost, Azita Alam Rajabi, Mahdi Mosavi Jarrahi, Seyed Alireza Goodarzi, Mark O. J Cell Mol Med Original Articles Breast cancer (BC) is the leading cause of cancer‐related deaths in females worldwide and is related to genetic and environmental factors. Dietary components may strongly influence the risk of BC. A possible association was also reported between the fat mass and obesity‐associated (FTO) single‐nucleotide polymorphisms (SNPs) and BC. This study aimed to investigate the impact of FTO rs9939609 polymorphism on the association between BC and dietary intake. This study was conducted on 180 women with BC as the case group and 360 healthy women as the control group. The dietary intakes were assessed by a valid 168‐item food frequency questionnaire (FFQ). The FTO gene was genotyped for rs9939609 polymorphism. After adjusting the confounding variables, there was no significant association between dietary intake and BC in individuals without risk allele. A positive association between dietary intake of omega‐6 fatty acids and BC was found only in individuals with risk allele of FTO gene (OR: 1.31, 95% CI: 1.08–1.60, p: 0.006). FTO gene risk allele may influence the effect of diet on breast cancer risk. Further studies are needed to assess the possible effects of the FTO genotype on the association between BC risk and dietary components. John Wiley and Sons Inc. 2022-11-20 2022-12 /pmc/articles/PMC9716323/ /pubmed/36403211 http://dx.doi.org/10.1111/jcmm.17595 Text en © 2022 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Doaei, Saeid Abdollahi, Sepideh Mohseni, Golsa Khalatbari Gholamalizadeh, Maryam Akbari, Mohammad Esmail Poorhosseini, Seyed Mohammad Bagheri, Seyedeh Elaheh Ghafouri‐Fard, Soudeh Tabesh, Ghasem Azizi Moslem, Alireza Hasanpour Ardekanizadeh, Naeemeh Omidi, Saeed Hekmatdoost, Azita Alam Rajabi, Mahdi Mosavi Jarrahi, Seyed Alireza Goodarzi, Mark O. The effects of FTO gene rs9939609 polymorphism on the association between breast cancer and dietary intake |
title | The effects of FTO gene rs9939609 polymorphism on the association between breast cancer and dietary intake |
title_full | The effects of FTO gene rs9939609 polymorphism on the association between breast cancer and dietary intake |
title_fullStr | The effects of FTO gene rs9939609 polymorphism on the association between breast cancer and dietary intake |
title_full_unstemmed | The effects of FTO gene rs9939609 polymorphism on the association between breast cancer and dietary intake |
title_short | The effects of FTO gene rs9939609 polymorphism on the association between breast cancer and dietary intake |
title_sort | effects of fto gene rs9939609 polymorphism on the association between breast cancer and dietary intake |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716323/ https://www.ncbi.nlm.nih.gov/pubmed/36403211 http://dx.doi.org/10.1111/jcmm.17595 |
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