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The effects of FTO gene rs9939609 polymorphism on the association between breast cancer and dietary intake

Breast cancer (BC) is the leading cause of cancer‐related deaths in females worldwide and is related to genetic and environmental factors. Dietary components may strongly influence the risk of BC. A possible association was also reported between the fat mass and obesity‐associated (FTO) single‐nucle...

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Autores principales: Doaei, Saeid, Abdollahi, Sepideh, Mohseni, Golsa Khalatbari, Gholamalizadeh, Maryam, Akbari, Mohammad Esmail, Poorhosseini, Seyed Mohammad, Bagheri, Seyedeh Elaheh, Ghafouri‐Fard, Soudeh, Tabesh, Ghasem Azizi, Moslem, Alireza, Hasanpour Ardekanizadeh, Naeemeh, Omidi, Saeed, Hekmatdoost, Azita, Alam Rajabi, Mahdi, Mosavi Jarrahi, Seyed Alireza, Goodarzi, Mark O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716323/
https://www.ncbi.nlm.nih.gov/pubmed/36403211
http://dx.doi.org/10.1111/jcmm.17595
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author Doaei, Saeid
Abdollahi, Sepideh
Mohseni, Golsa Khalatbari
Gholamalizadeh, Maryam
Akbari, Mohammad Esmail
Poorhosseini, Seyed Mohammad
Bagheri, Seyedeh Elaheh
Ghafouri‐Fard, Soudeh
Tabesh, Ghasem Azizi
Moslem, Alireza
Hasanpour Ardekanizadeh, Naeemeh
Omidi, Saeed
Hekmatdoost, Azita
Alam Rajabi, Mahdi
Mosavi Jarrahi, Seyed Alireza
Goodarzi, Mark O.
author_facet Doaei, Saeid
Abdollahi, Sepideh
Mohseni, Golsa Khalatbari
Gholamalizadeh, Maryam
Akbari, Mohammad Esmail
Poorhosseini, Seyed Mohammad
Bagheri, Seyedeh Elaheh
Ghafouri‐Fard, Soudeh
Tabesh, Ghasem Azizi
Moslem, Alireza
Hasanpour Ardekanizadeh, Naeemeh
Omidi, Saeed
Hekmatdoost, Azita
Alam Rajabi, Mahdi
Mosavi Jarrahi, Seyed Alireza
Goodarzi, Mark O.
author_sort Doaei, Saeid
collection PubMed
description Breast cancer (BC) is the leading cause of cancer‐related deaths in females worldwide and is related to genetic and environmental factors. Dietary components may strongly influence the risk of BC. A possible association was also reported between the fat mass and obesity‐associated (FTO) single‐nucleotide polymorphisms (SNPs) and BC. This study aimed to investigate the impact of FTO rs9939609 polymorphism on the association between BC and dietary intake. This study was conducted on 180 women with BC as the case group and 360 healthy women as the control group. The dietary intakes were assessed by a valid 168‐item food frequency questionnaire (FFQ). The FTO gene was genotyped for rs9939609 polymorphism. After adjusting the confounding variables, there was no significant association between dietary intake and BC in individuals without risk allele. A positive association between dietary intake of omega‐6 fatty acids and BC was found only in individuals with risk allele of FTO gene (OR: 1.31, 95% CI: 1.08–1.60, p: 0.006). FTO gene risk allele may influence the effect of diet on breast cancer risk. Further studies are needed to assess the possible effects of the FTO genotype on the association between BC risk and dietary components.
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spelling pubmed-97163232022-12-05 The effects of FTO gene rs9939609 polymorphism on the association between breast cancer and dietary intake Doaei, Saeid Abdollahi, Sepideh Mohseni, Golsa Khalatbari Gholamalizadeh, Maryam Akbari, Mohammad Esmail Poorhosseini, Seyed Mohammad Bagheri, Seyedeh Elaheh Ghafouri‐Fard, Soudeh Tabesh, Ghasem Azizi Moslem, Alireza Hasanpour Ardekanizadeh, Naeemeh Omidi, Saeed Hekmatdoost, Azita Alam Rajabi, Mahdi Mosavi Jarrahi, Seyed Alireza Goodarzi, Mark O. J Cell Mol Med Original Articles Breast cancer (BC) is the leading cause of cancer‐related deaths in females worldwide and is related to genetic and environmental factors. Dietary components may strongly influence the risk of BC. A possible association was also reported between the fat mass and obesity‐associated (FTO) single‐nucleotide polymorphisms (SNPs) and BC. This study aimed to investigate the impact of FTO rs9939609 polymorphism on the association between BC and dietary intake. This study was conducted on 180 women with BC as the case group and 360 healthy women as the control group. The dietary intakes were assessed by a valid 168‐item food frequency questionnaire (FFQ). The FTO gene was genotyped for rs9939609 polymorphism. After adjusting the confounding variables, there was no significant association between dietary intake and BC in individuals without risk allele. A positive association between dietary intake of omega‐6 fatty acids and BC was found only in individuals with risk allele of FTO gene (OR: 1.31, 95% CI: 1.08–1.60, p: 0.006). FTO gene risk allele may influence the effect of diet on breast cancer risk. Further studies are needed to assess the possible effects of the FTO genotype on the association between BC risk and dietary components. John Wiley and Sons Inc. 2022-11-20 2022-12 /pmc/articles/PMC9716323/ /pubmed/36403211 http://dx.doi.org/10.1111/jcmm.17595 Text en © 2022 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Doaei, Saeid
Abdollahi, Sepideh
Mohseni, Golsa Khalatbari
Gholamalizadeh, Maryam
Akbari, Mohammad Esmail
Poorhosseini, Seyed Mohammad
Bagheri, Seyedeh Elaheh
Ghafouri‐Fard, Soudeh
Tabesh, Ghasem Azizi
Moslem, Alireza
Hasanpour Ardekanizadeh, Naeemeh
Omidi, Saeed
Hekmatdoost, Azita
Alam Rajabi, Mahdi
Mosavi Jarrahi, Seyed Alireza
Goodarzi, Mark O.
The effects of FTO gene rs9939609 polymorphism on the association between breast cancer and dietary intake
title The effects of FTO gene rs9939609 polymorphism on the association between breast cancer and dietary intake
title_full The effects of FTO gene rs9939609 polymorphism on the association between breast cancer and dietary intake
title_fullStr The effects of FTO gene rs9939609 polymorphism on the association between breast cancer and dietary intake
title_full_unstemmed The effects of FTO gene rs9939609 polymorphism on the association between breast cancer and dietary intake
title_short The effects of FTO gene rs9939609 polymorphism on the association between breast cancer and dietary intake
title_sort effects of fto gene rs9939609 polymorphism on the association between breast cancer and dietary intake
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716323/
https://www.ncbi.nlm.nih.gov/pubmed/36403211
http://dx.doi.org/10.1111/jcmm.17595
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