Identification and Characterization of a Novel Dual Inhibitor of Indoleamine 2,3-dioxygenase 1 and Tryptophan 2,3-dioxygenase

Kynurenine (Kyn), a metabolite of tryptophan (Trp), is a key regulator of mammal immune responses such as cancer immune tolerance. Indoleamine-2,3-dioxygenase (IDO) and tryptophan-2,3-dioxygenase (TDO) are main enzymes regulating the first and rate-limiting step of the Kyn pathway. To identify new s...

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Detalles Bibliográficos
Autores principales: Yoshioka, Saeko, Ikeda, Tomonori, Fukuchi, Sogo, Kawai, Yurika, Ohta, Katsumi, Murakami, Hisashi, Ogo, Naohisa, Muraoka, Daisuke, Takikawa, Osamu, Asai, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716449/
https://www.ncbi.nlm.nih.gov/pubmed/36467776
http://dx.doi.org/10.1177/11786469221138456

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