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Dual wavelength retinal vessel oximetry – influence of fundus pigmentation

BACKGROUND: Clinical methods examining oxygenation parameters in humans have been used in many different care settings, but concerns have been raised regarding their clinical utility when assessing people with darker skin pigmentation. While saturation values can be crucial in emergency medicine, th...

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Autores principales: Hirsch, Katrin, Cubbidge, Robert P., Heitmar, Rebekka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716545/
https://www.ncbi.nlm.nih.gov/pubmed/36460856
http://dx.doi.org/10.1038/s41433-022-02325-7
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author Hirsch, Katrin
Cubbidge, Robert P.
Heitmar, Rebekka
author_facet Hirsch, Katrin
Cubbidge, Robert P.
Heitmar, Rebekka
author_sort Hirsch, Katrin
collection PubMed
description BACKGROUND: Clinical methods examining oxygenation parameters in humans have been used in many different care settings, but concerns have been raised regarding their clinical utility when assessing people with darker skin pigmentation. While saturation values can be crucial in emergency medicine, they are equally valuable in assessing disease mechanisms and monitoring change in disease progression. Retinal pigmentation varies across individuals and hence, can impact on retinal oxygen parameters. The objective of this study was to quantify and eliminate the impact of retinal pigmentation on retinal vessel oxygen saturation parameters measured in the superficial retinal arterioles and venules. METHODS: 105 healthy individuals of varying skin colour, iris colour and heritage were included. Following a full eye exam to exclude any ocular abnormality, all participants underwent intraocular pressure, systemic blood pressure measurements and dilated dual wavelength retinal photography. Rotation matrices were employed to minimise the dependency of retinal pigmentation on arterial and venous oxygen saturation measurements determined in a concentric measurement annulus. RESULTS: Retinal oxygen saturation in venules showed a linear correlation with retinal pigmentation (y = 0.34 × x + 38.598), whereas arterial saturation followed a polynomial pattern (y = 0.0089 × x(2) + 0.7499 × x + 85.073). Both arterial and venous saturation values were corrected using local fundus pigmentation. Pre-correction retinal arterial and venous oxygen saturation were 89.0% (±13.1) and 43.7% (±11.5), respectively, and post- correction values were 94.8% (±8.7) for arteries and 56.3% (±7.0) veins. CONCLUSIONS: When assessing multi-ethnic cohorts, it is important to consider the impact of pigmentation on imaging parameters and to account for it prior to clinical interpretation.
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spelling pubmed-97165452022-12-02 Dual wavelength retinal vessel oximetry – influence of fundus pigmentation Hirsch, Katrin Cubbidge, Robert P. Heitmar, Rebekka Eye (Lond) Article BACKGROUND: Clinical methods examining oxygenation parameters in humans have been used in many different care settings, but concerns have been raised regarding their clinical utility when assessing people with darker skin pigmentation. While saturation values can be crucial in emergency medicine, they are equally valuable in assessing disease mechanisms and monitoring change in disease progression. Retinal pigmentation varies across individuals and hence, can impact on retinal oxygen parameters. The objective of this study was to quantify and eliminate the impact of retinal pigmentation on retinal vessel oxygen saturation parameters measured in the superficial retinal arterioles and venules. METHODS: 105 healthy individuals of varying skin colour, iris colour and heritage were included. Following a full eye exam to exclude any ocular abnormality, all participants underwent intraocular pressure, systemic blood pressure measurements and dilated dual wavelength retinal photography. Rotation matrices were employed to minimise the dependency of retinal pigmentation on arterial and venous oxygen saturation measurements determined in a concentric measurement annulus. RESULTS: Retinal oxygen saturation in venules showed a linear correlation with retinal pigmentation (y = 0.34 × x + 38.598), whereas arterial saturation followed a polynomial pattern (y = 0.0089 × x(2) + 0.7499 × x + 85.073). Both arterial and venous saturation values were corrected using local fundus pigmentation. Pre-correction retinal arterial and venous oxygen saturation were 89.0% (±13.1) and 43.7% (±11.5), respectively, and post- correction values were 94.8% (±8.7) for arteries and 56.3% (±7.0) veins. CONCLUSIONS: When assessing multi-ethnic cohorts, it is important to consider the impact of pigmentation on imaging parameters and to account for it prior to clinical interpretation. Nature Publishing Group UK 2022-12-02 2023-08 /pmc/articles/PMC9716545/ /pubmed/36460856 http://dx.doi.org/10.1038/s41433-022-02325-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Article
Hirsch, Katrin
Cubbidge, Robert P.
Heitmar, Rebekka
Dual wavelength retinal vessel oximetry – influence of fundus pigmentation
title Dual wavelength retinal vessel oximetry – influence of fundus pigmentation
title_full Dual wavelength retinal vessel oximetry – influence of fundus pigmentation
title_fullStr Dual wavelength retinal vessel oximetry – influence of fundus pigmentation
title_full_unstemmed Dual wavelength retinal vessel oximetry – influence of fundus pigmentation
title_short Dual wavelength retinal vessel oximetry – influence of fundus pigmentation
title_sort dual wavelength retinal vessel oximetry – influence of fundus pigmentation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716545/
https://www.ncbi.nlm.nih.gov/pubmed/36460856
http://dx.doi.org/10.1038/s41433-022-02325-7
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