NF1 loss of function as an alternative initiating event in pancreatic ductal adenocarcinoma

A long-standing question in the pancreatic ductal adenocarcinoma (PDAC) field has been whether alternative genetic alterations could substitute for oncogenic KRAS mutations in initiating malignancy. Here, we report that Neurofibromin1 (NF1) inactivation can bypass the requirement of mutant KRAS for...

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Detalles Bibliográficos
Autores principales: Ramakrishnan, Gopalakrishnan, Parajuli, Parash, Singh, Pura, Friend, Creighton, Hurwitz, Eric, Prunier, Celine, Razzaque, Mohammed S., Xu, Keli, Atfi, Azeddine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716579/
https://www.ncbi.nlm.nih.gov/pubmed/36351408
http://dx.doi.org/10.1016/j.celrep.2022.111623

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