Cargando…

Drug purchases prior to conception and the risk of gestational diabetes mellitus

OBJECTIVE: Some drugs have adverse effects on glucose metabolism, but it is unknown whether prescription drugs used prior to conception influence the future risk of gestational diabetes mellitus (GDM). Our study evaluated whether the purchase of prescription drugs 6 months prior to conception was as...

Descripción completa

Detalles Bibliográficos
Autores principales: Laine, Merja K., Kautiainen, Hannu, Gissler, Mika, Pennanen, Pirjo, Eriksson, Johan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716604/
https://www.ncbi.nlm.nih.gov/pubmed/36446764
http://dx.doi.org/10.1177/03000605221138455
_version_ 1784842727513391104
author Laine, Merja K.
Kautiainen, Hannu
Gissler, Mika
Pennanen, Pirjo
Eriksson, Johan G.
author_facet Laine, Merja K.
Kautiainen, Hannu
Gissler, Mika
Pennanen, Pirjo
Eriksson, Johan G.
author_sort Laine, Merja K.
collection PubMed
description OBJECTIVE: Some drugs have adverse effects on glucose metabolism, but it is unknown whether prescription drugs used prior to conception influence the future risk of gestational diabetes mellitus (GDM). Our study evaluated whether the purchase of prescription drugs 6 months prior to conception was associated with the occurrence of GDM. METHODS: This cohort study enrolled women with a Finnish background who delivered between 2009 and 2015 in the city of Vantaa, Finland (N = 10,455). Data on maternal characteristics and prescription drug purchases were obtained from national health registers. The use of a unique personal identification number enabled us to combine the register data on an individual level. RESULTS: Six months prior to conception, women who had pregnancies complicated by GDM purchased more prescription drugs than women without GDM (1.38 ± 2.04 vs. 1.11 ± 1.80). The GDM risk was higher in women with higher numbers of prescription purchases and those with more than three deliveries. CONCLUSIONS: Multiparous women who purchase several prescription drugs should be given personalized counseling to prevent GDM.
format Online
Article
Text
id pubmed-9716604
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-97166042022-12-03 Drug purchases prior to conception and the risk of gestational diabetes mellitus Laine, Merja K. Kautiainen, Hannu Gissler, Mika Pennanen, Pirjo Eriksson, Johan G. J Int Med Res Retrospective Clinical Research Report OBJECTIVE: Some drugs have adverse effects on glucose metabolism, but it is unknown whether prescription drugs used prior to conception influence the future risk of gestational diabetes mellitus (GDM). Our study evaluated whether the purchase of prescription drugs 6 months prior to conception was associated with the occurrence of GDM. METHODS: This cohort study enrolled women with a Finnish background who delivered between 2009 and 2015 in the city of Vantaa, Finland (N = 10,455). Data on maternal characteristics and prescription drug purchases were obtained from national health registers. The use of a unique personal identification number enabled us to combine the register data on an individual level. RESULTS: Six months prior to conception, women who had pregnancies complicated by GDM purchased more prescription drugs than women without GDM (1.38 ± 2.04 vs. 1.11 ± 1.80). The GDM risk was higher in women with higher numbers of prescription purchases and those with more than three deliveries. CONCLUSIONS: Multiparous women who purchase several prescription drugs should be given personalized counseling to prevent GDM. SAGE Publications 2022-11-29 /pmc/articles/PMC9716604/ /pubmed/36446764 http://dx.doi.org/10.1177/03000605221138455 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Retrospective Clinical Research Report
Laine, Merja K.
Kautiainen, Hannu
Gissler, Mika
Pennanen, Pirjo
Eriksson, Johan G.
Drug purchases prior to conception and the risk of gestational diabetes mellitus
title Drug purchases prior to conception and the risk of gestational diabetes mellitus
title_full Drug purchases prior to conception and the risk of gestational diabetes mellitus
title_fullStr Drug purchases prior to conception and the risk of gestational diabetes mellitus
title_full_unstemmed Drug purchases prior to conception and the risk of gestational diabetes mellitus
title_short Drug purchases prior to conception and the risk of gestational diabetes mellitus
title_sort drug purchases prior to conception and the risk of gestational diabetes mellitus
topic Retrospective Clinical Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716604/
https://www.ncbi.nlm.nih.gov/pubmed/36446764
http://dx.doi.org/10.1177/03000605221138455
work_keys_str_mv AT lainemerjak drugpurchasespriortoconceptionandtheriskofgestationaldiabetesmellitus
AT kautiainenhannu drugpurchasespriortoconceptionandtheriskofgestationaldiabetesmellitus
AT gisslermika drugpurchasespriortoconceptionandtheriskofgestationaldiabetesmellitus
AT pennanenpirjo drugpurchasespriortoconceptionandtheriskofgestationaldiabetesmellitus
AT erikssonjohang drugpurchasespriortoconceptionandtheriskofgestationaldiabetesmellitus