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Drug purchases prior to conception and the risk of gestational diabetes mellitus
OBJECTIVE: Some drugs have adverse effects on glucose metabolism, but it is unknown whether prescription drugs used prior to conception influence the future risk of gestational diabetes mellitus (GDM). Our study evaluated whether the purchase of prescription drugs 6 months prior to conception was as...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716604/ https://www.ncbi.nlm.nih.gov/pubmed/36446764 http://dx.doi.org/10.1177/03000605221138455 |
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author | Laine, Merja K. Kautiainen, Hannu Gissler, Mika Pennanen, Pirjo Eriksson, Johan G. |
author_facet | Laine, Merja K. Kautiainen, Hannu Gissler, Mika Pennanen, Pirjo Eriksson, Johan G. |
author_sort | Laine, Merja K. |
collection | PubMed |
description | OBJECTIVE: Some drugs have adverse effects on glucose metabolism, but it is unknown whether prescription drugs used prior to conception influence the future risk of gestational diabetes mellitus (GDM). Our study evaluated whether the purchase of prescription drugs 6 months prior to conception was associated with the occurrence of GDM. METHODS: This cohort study enrolled women with a Finnish background who delivered between 2009 and 2015 in the city of Vantaa, Finland (N = 10,455). Data on maternal characteristics and prescription drug purchases were obtained from national health registers. The use of a unique personal identification number enabled us to combine the register data on an individual level. RESULTS: Six months prior to conception, women who had pregnancies complicated by GDM purchased more prescription drugs than women without GDM (1.38 ± 2.04 vs. 1.11 ± 1.80). The GDM risk was higher in women with higher numbers of prescription purchases and those with more than three deliveries. CONCLUSIONS: Multiparous women who purchase several prescription drugs should be given personalized counseling to prevent GDM. |
format | Online Article Text |
id | pubmed-9716604 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-97166042022-12-03 Drug purchases prior to conception and the risk of gestational diabetes mellitus Laine, Merja K. Kautiainen, Hannu Gissler, Mika Pennanen, Pirjo Eriksson, Johan G. J Int Med Res Retrospective Clinical Research Report OBJECTIVE: Some drugs have adverse effects on glucose metabolism, but it is unknown whether prescription drugs used prior to conception influence the future risk of gestational diabetes mellitus (GDM). Our study evaluated whether the purchase of prescription drugs 6 months prior to conception was associated with the occurrence of GDM. METHODS: This cohort study enrolled women with a Finnish background who delivered between 2009 and 2015 in the city of Vantaa, Finland (N = 10,455). Data on maternal characteristics and prescription drug purchases were obtained from national health registers. The use of a unique personal identification number enabled us to combine the register data on an individual level. RESULTS: Six months prior to conception, women who had pregnancies complicated by GDM purchased more prescription drugs than women without GDM (1.38 ± 2.04 vs. 1.11 ± 1.80). The GDM risk was higher in women with higher numbers of prescription purchases and those with more than three deliveries. CONCLUSIONS: Multiparous women who purchase several prescription drugs should be given personalized counseling to prevent GDM. SAGE Publications 2022-11-29 /pmc/articles/PMC9716604/ /pubmed/36446764 http://dx.doi.org/10.1177/03000605221138455 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Retrospective Clinical Research Report Laine, Merja K. Kautiainen, Hannu Gissler, Mika Pennanen, Pirjo Eriksson, Johan G. Drug purchases prior to conception and the risk of gestational diabetes mellitus |
title | Drug purchases prior to conception and the risk of gestational diabetes mellitus |
title_full | Drug purchases prior to conception and the risk of gestational diabetes mellitus |
title_fullStr | Drug purchases prior to conception and the risk of gestational diabetes mellitus |
title_full_unstemmed | Drug purchases prior to conception and the risk of gestational diabetes mellitus |
title_short | Drug purchases prior to conception and the risk of gestational diabetes mellitus |
title_sort | drug purchases prior to conception and the risk of gestational diabetes mellitus |
topic | Retrospective Clinical Research Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716604/ https://www.ncbi.nlm.nih.gov/pubmed/36446764 http://dx.doi.org/10.1177/03000605221138455 |
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