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Is SARS-CoV-2 viral load a predictor of mortality in COVID-19 acute respiratory distress syndrome patients?
OBJECTIVE: Viral load varies during infection and is higher during the initial stages of disease. Given the importance of the intensive care unit (ICU) in the late stages of COVID-19 infection, analyzing cycle threshold values to detect viral load upon ICU admission can be a clinically valuable tool...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716617/ https://www.ncbi.nlm.nih.gov/pubmed/36448528 http://dx.doi.org/10.1177/03000605221137443 |
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author | Dogan, Lerzan Allahverdiyeva, Aytaj Önel, Mustafa Meşe, Sevim Saka Ersin, Esra Anaklı, İlkay Sarıkaya, Zeynep Tuğçe Zengin, Rehile Gucyetmez, Bulent Yurtturan Uyar, Neval Özcan, Perihan Ergin Kocagöz, Ayse Sesin Uysal, Hayriye Kırkoyun Akinci, İbrahim Ozkan Ağaçfidan, Ali |
author_facet | Dogan, Lerzan Allahverdiyeva, Aytaj Önel, Mustafa Meşe, Sevim Saka Ersin, Esra Anaklı, İlkay Sarıkaya, Zeynep Tuğçe Zengin, Rehile Gucyetmez, Bulent Yurtturan Uyar, Neval Özcan, Perihan Ergin Kocagöz, Ayse Sesin Uysal, Hayriye Kırkoyun Akinci, İbrahim Ozkan Ağaçfidan, Ali |
author_sort | Dogan, Lerzan |
collection | PubMed |
description | OBJECTIVE: Viral load varies during infection and is higher during the initial stages of disease. Given the importance of the intensive care unit (ICU) in the late stages of COVID-19 infection, analyzing cycle threshold values to detect viral load upon ICU admission can be a clinically valuable tool for identifying patients with the highest mortality risk. METHODS: This was a retrospectively designed study. Patients older than 18 years who tested positive for SARS-CoV-2 PCR and had a PaO(2)/FiO(2) ratio <200 were included in the study. The patient population was divided into two groups: survivors and non-survivors. RESULTS: Two hundred patients were included in the study. In non-survivors, age, relevant ICU admission scores, and procalcitonin levels were significantly higher whereas PaO(2)/FiO(2) ratios and cycle threshold levels were significantly lower than in survivors. CONCLUSION: Viral load at ICU admission has significant prognostic value. In combination with age, comorbidities, and severity scores, viral load may assist clinicians in identifying individuals who need more intensive monitoring. Increased awareness may improve outcomes by allowing the more effective monitoring and treatment of patients. More prospective studies are needed to determine how a high viral load worsens disease and how to avoid irreversible results. |
format | Online Article Text |
id | pubmed-9716617 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-97166172022-12-03 Is SARS-CoV-2 viral load a predictor of mortality in COVID-19 acute respiratory distress syndrome patients? Dogan, Lerzan Allahverdiyeva, Aytaj Önel, Mustafa Meşe, Sevim Saka Ersin, Esra Anaklı, İlkay Sarıkaya, Zeynep Tuğçe Zengin, Rehile Gucyetmez, Bulent Yurtturan Uyar, Neval Özcan, Perihan Ergin Kocagöz, Ayse Sesin Uysal, Hayriye Kırkoyun Akinci, İbrahim Ozkan Ağaçfidan, Ali J Int Med Res Retrospective Clinical Research Report OBJECTIVE: Viral load varies during infection and is higher during the initial stages of disease. Given the importance of the intensive care unit (ICU) in the late stages of COVID-19 infection, analyzing cycle threshold values to detect viral load upon ICU admission can be a clinically valuable tool for identifying patients with the highest mortality risk. METHODS: This was a retrospectively designed study. Patients older than 18 years who tested positive for SARS-CoV-2 PCR and had a PaO(2)/FiO(2) ratio <200 were included in the study. The patient population was divided into two groups: survivors and non-survivors. RESULTS: Two hundred patients were included in the study. In non-survivors, age, relevant ICU admission scores, and procalcitonin levels were significantly higher whereas PaO(2)/FiO(2) ratios and cycle threshold levels were significantly lower than in survivors. CONCLUSION: Viral load at ICU admission has significant prognostic value. In combination with age, comorbidities, and severity scores, viral load may assist clinicians in identifying individuals who need more intensive monitoring. Increased awareness may improve outcomes by allowing the more effective monitoring and treatment of patients. More prospective studies are needed to determine how a high viral load worsens disease and how to avoid irreversible results. SAGE Publications 2022-11-30 /pmc/articles/PMC9716617/ /pubmed/36448528 http://dx.doi.org/10.1177/03000605221137443 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Retrospective Clinical Research Report Dogan, Lerzan Allahverdiyeva, Aytaj Önel, Mustafa Meşe, Sevim Saka Ersin, Esra Anaklı, İlkay Sarıkaya, Zeynep Tuğçe Zengin, Rehile Gucyetmez, Bulent Yurtturan Uyar, Neval Özcan, Perihan Ergin Kocagöz, Ayse Sesin Uysal, Hayriye Kırkoyun Akinci, İbrahim Ozkan Ağaçfidan, Ali Is SARS-CoV-2 viral load a predictor of mortality in COVID-19 acute respiratory distress syndrome patients? |
title | Is SARS-CoV-2 viral load a predictor of mortality in COVID-19 acute respiratory distress syndrome patients? |
title_full | Is SARS-CoV-2 viral load a predictor of mortality in COVID-19 acute respiratory distress syndrome patients? |
title_fullStr | Is SARS-CoV-2 viral load a predictor of mortality in COVID-19 acute respiratory distress syndrome patients? |
title_full_unstemmed | Is SARS-CoV-2 viral load a predictor of mortality in COVID-19 acute respiratory distress syndrome patients? |
title_short | Is SARS-CoV-2 viral load a predictor of mortality in COVID-19 acute respiratory distress syndrome patients? |
title_sort | is sars-cov-2 viral load a predictor of mortality in covid-19 acute respiratory distress syndrome patients? |
topic | Retrospective Clinical Research Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716617/ https://www.ncbi.nlm.nih.gov/pubmed/36448528 http://dx.doi.org/10.1177/03000605221137443 |
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