Severe mpox (formerly monkeypox) disease in five patients after recent vaccination with MVA-BN vaccine, Belgium, July to October 2022

Vaccination is important in containing the 2022 mpox (formerly monkeypox) epidemic. We describe five Belgian patients with localised severe symptoms of proctitis and penile oedema, occurring between 4 and 35 days after post-exposure preventive vaccination or after one- or two-dose off-label pre-expo...

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Detalles Bibliográficos
Autores principales: Berens-Riha, Nicole, De Block, Tessa, Rutgers, Jojanneke, Michiels, Johan, Van Gestel, Liesbeth, Hens, Matilde, Kenyon, Chris, Bottieau, Emmanuel, Soentjens, Patrick, van Griensven, Johan, Brosius, Isabel, Ariën, Kevin K, Van Esbroeck, Marjan, Rezende, Antonio Mauro, Vercauteren, Koen, Liesenborghs, Laurens, Van Dijck, Christophe, De Baetselier, Irith, Van den Bossche, Dorien, Florence, Eric, Adriaensen, Wim, Coppens, Jasmine, Vanroye, Fien, Ramadan, Kadrie, Van Looveren, Karin, Baeyens, Jolien, Heyndrickx, Leo, Rasson, Hanne, Verschueren, Jacob, Bracke, Stefanie, Vandenhove, Leen, Vanhamel, Jef, Vuylsteke, Bea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2022
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716643/
https://www.ncbi.nlm.nih.gov/pubmed/36695462
http://dx.doi.org/10.2807/1560-7917.ES.2022.27.48.2200894
Descripción
Sumario:Vaccination is important in containing the 2022 mpox (formerly monkeypox) epidemic. We describe five Belgian patients with localised severe symptoms of proctitis and penile oedema, occurring between 4 and 35 days after post-exposure preventive vaccination or after one- or two-dose off-label pre-exposure preventive vaccination with MVA-BN vaccine. Genome sequencing did not reveal evidence for immune escape variants. Healthcare workers and those at risk should be aware of possible infections occurring shortly after vaccination and the need for other preventive measures.

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