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Receptor editing constrains development of phosphatidyl choline-specific B cells in V(H)12-transgenic mice
B1 B cells reactive to phosphatidyl choline (PtC) exhibit restricted immunoglobulin heavy chain (HC) and light chain (LC) combinations, exemplified by V(H)12/Vκ4/5H. Two checkpoints are thought to focus PtC(+) B cell maturation in V(H)12-transgenic mice (VH12 mice): V-J rearrangements encoding a “pe...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716649/ https://www.ncbi.nlm.nih.gov/pubmed/35705027 http://dx.doi.org/10.1016/j.celrep.2022.110899 |