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Non-coding RNA and n6-methyladenosine modification play crucial roles in neuropathic pain
After peripheral nerve injury, pain signals are transmitted from primary sensory neurons in the dorsal root ganglion (DRG) to the central nervous system. Epigenetic modification affects neuropathic pain through alterations in the gene expression in pain-related areas and glial cell activation. Recen...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716653/ https://www.ncbi.nlm.nih.gov/pubmed/36466810 http://dx.doi.org/10.3389/fnmol.2022.1002018 |
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author | Zhang, Kexin Li, Pei Jia, Yuanyuan Liu, Ming Jiang, Jingjing |
author_facet | Zhang, Kexin Li, Pei Jia, Yuanyuan Liu, Ming Jiang, Jingjing |
author_sort | Zhang, Kexin |
collection | PubMed |
description | After peripheral nerve injury, pain signals are transmitted from primary sensory neurons in the dorsal root ganglion (DRG) to the central nervous system. Epigenetic modification affects neuropathic pain through alterations in the gene expression in pain-related areas and glial cell activation. Recent studies have shown that non-coding RNA and n6-methyladenosine (m6A) methylation modification play pivotal regulatory roles in the occurrence and maintenance of neuropathic pain. Dysregulation of the RNA m6A level via dynamic changes in methyltransferase and demethylase after central or peripheral nerve injury commonly regulates pain-associated genes, contributing to the induction and maintenance of neuropathic pain. The dynamic process has significant implications for the development and maintenance of neuropathic pain. However, the underlying mechanisms by which non-coding RNA and m6A RNA modification regulate neuropathic pain are not well-characterized. This article elucidates the multiple mechanisms of non-coding RNA and m6A methylation in the context of neuropathic pain, and summarizes its potential functions as well as recent advances. |
format | Online Article Text |
id | pubmed-9716653 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97166532022-12-03 Non-coding RNA and n6-methyladenosine modification play crucial roles in neuropathic pain Zhang, Kexin Li, Pei Jia, Yuanyuan Liu, Ming Jiang, Jingjing Front Mol Neurosci Neuroscience After peripheral nerve injury, pain signals are transmitted from primary sensory neurons in the dorsal root ganglion (DRG) to the central nervous system. Epigenetic modification affects neuropathic pain through alterations in the gene expression in pain-related areas and glial cell activation. Recent studies have shown that non-coding RNA and n6-methyladenosine (m6A) methylation modification play pivotal regulatory roles in the occurrence and maintenance of neuropathic pain. Dysregulation of the RNA m6A level via dynamic changes in methyltransferase and demethylase after central or peripheral nerve injury commonly regulates pain-associated genes, contributing to the induction and maintenance of neuropathic pain. The dynamic process has significant implications for the development and maintenance of neuropathic pain. However, the underlying mechanisms by which non-coding RNA and m6A RNA modification regulate neuropathic pain are not well-characterized. This article elucidates the multiple mechanisms of non-coding RNA and m6A methylation in the context of neuropathic pain, and summarizes its potential functions as well as recent advances. Frontiers Media S.A. 2022-11-16 /pmc/articles/PMC9716653/ /pubmed/36466810 http://dx.doi.org/10.3389/fnmol.2022.1002018 Text en Copyright © 2022 Zhang, Li, Jia, Liu and Jiang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Zhang, Kexin Li, Pei Jia, Yuanyuan Liu, Ming Jiang, Jingjing Non-coding RNA and n6-methyladenosine modification play crucial roles in neuropathic pain |
title | Non-coding RNA and n6-methyladenosine modification play crucial roles in neuropathic pain |
title_full | Non-coding RNA and n6-methyladenosine modification play crucial roles in neuropathic pain |
title_fullStr | Non-coding RNA and n6-methyladenosine modification play crucial roles in neuropathic pain |
title_full_unstemmed | Non-coding RNA and n6-methyladenosine modification play crucial roles in neuropathic pain |
title_short | Non-coding RNA and n6-methyladenosine modification play crucial roles in neuropathic pain |
title_sort | non-coding rna and n6-methyladenosine modification play crucial roles in neuropathic pain |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716653/ https://www.ncbi.nlm.nih.gov/pubmed/36466810 http://dx.doi.org/10.3389/fnmol.2022.1002018 |
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