METTL4-mediated nuclear N6-deoxyadenosine methylation promotes metastasis through activating multiple metastasis-inducing targets

BACKGROUND: DNA N6-methyldeoxyadenosine (6mA) is rarely present in mammalian cells and its nuclear role remains elusive. RESULTS: Here we show that hypoxia induces nuclear 6mA modification through a DNA methyltransferase, METTL4, in hypoxia-induced epithelial-mesenchymal transition (EMT) and tumor m...

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Detalles Bibliográficos
Autores principales: Hsu, Kai-Wen, Lai, Joseph Chieh-Yu, Chang, Jeng-Shou, Peng, Pei-Hua, Huang, Ching-Hui, Lee, Der-Yen, Tsai, Yu-Cheng, Chung, Chi-Jung, Chang, Han, Chang, Chao-Hsiang, Chen, Ji-Lin, Pang, See-Tong, Hao, Ziyang, Cui, Xiao-Long, He, Chuan, Wu, Kou-Juey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716733/
https://www.ncbi.nlm.nih.gov/pubmed/36461076
http://dx.doi.org/10.1186/s13059-022-02819-3

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