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Mechanosensitive piezo1 calcium channel activates connexin 43 hemichannels through PI3K signaling pathway in bone

BACKGROUND: Mechanical loading promotes bone formation and osteocytes are a major mechanosensory cell in the bone. Both Piezo1 channels and connexin 43 hemichannels (Cx43 HCs) in osteocytes are important players in mechanotransduction and anabolic function by mechanical loading. However, the mechani...

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Detalles Bibliográficos
Autores principales:	Zeng, Yan, Riquelme, Manuel A., Hua, Rui, Zhang, Jingruo, Acosta, Francisca M., Gu, Sumin, Jiang, Jean X.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716748/ https://www.ncbi.nlm.nih.gov/pubmed/36457052 http://dx.doi.org/10.1186/s13578-022-00929-w

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