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Quality of life outcomes in children after surgery for Hirschsprung disease and anorectal malformations: a systematic review and meta-analysis

BACKGROUND: No systematic review and meta-analysis to date has examined multiple child and parent-reported social and physical quality of life (QoL) in pediatric populations affected by Hirschsprung’s disease (HD) and anorectal malformations (ARM). The objective of this systematic review is to quant...

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Autores principales: Oltean, Irina, Hayawi, Lamia, Larocca, Victoria, Bijelić, Vid, Beveridge, Emily, Kaur, Manvinder, Grandpierre, Viviane, Kanyinda, Jane, Nasr, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716859/
https://www.ncbi.nlm.nih.gov/pubmed/36474732
http://dx.doi.org/10.1136/wjps-2022-000447
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author Oltean, Irina
Hayawi, Lamia
Larocca, Victoria
Bijelić, Vid
Beveridge, Emily
Kaur, Manvinder
Grandpierre, Viviane
Kanyinda, Jane
Nasr, Ahmed
author_facet Oltean, Irina
Hayawi, Lamia
Larocca, Victoria
Bijelić, Vid
Beveridge, Emily
Kaur, Manvinder
Grandpierre, Viviane
Kanyinda, Jane
Nasr, Ahmed
author_sort Oltean, Irina
collection PubMed
description BACKGROUND: No systematic review and meta-analysis to date has examined multiple child and parent-reported social and physical quality of life (QoL) in pediatric populations affected by Hirschsprung’s disease (HD) and anorectal malformations (ARM). The objective of this systematic review is to quantitatively summarize the parent-reported and child-reported psychosocial and physical functioning scores of such children. METHODS: Records were sourced from the CENTRAL, EMBASE, and MEDLINE databases. Studies that reported child and parent reported QoL in children with HD and ARM, regardless of surgery intervention, versus children without HD and ARM, were included. The primary outcome was the psychosocial functioning scores, and the secondary outcomes were the presence of postoperative constipation, postoperative obstruction symptoms, fecal incontinence, and enterocolitis. A random effects meta-analysis was used. RESULTS: Twenty-three studies were included in the systematic review, with 11 studies included in the meta-analysis. Totally, 1678 total pediatric patients with HD and ARM underwent surgery vs 392 healthy controls. Pooled parent-reported standardized mean (SM) scores showed better social functioning after surgery (SM 91.79, 95% CI (80.3 to 103.3), I(2)=0). The pooled standardized mean difference (SMD) showed evidence for parent-reported incontinence but not for constipation in children with HD and ARM after surgery that had a lower mean QoL score compared with the normal population (SMD −1.24 (-1.79 to –0.69), I(2)=76% and SMD −0.45, 95% CI (−1.12 to 0.21), I(2)=75%). The pooled prevalence of child-reported constipation was 22% (95% CI (16% to 28%), I(2)=0%). The pooled prevalence of parent-reported postoperative obstruction symptoms was 61% (95% CI (41% to 81%), I(2)=41%). CONCLUSION: The results demonstrate better social functioning after surgery, lower QoL scores for incontinence versus controls, and remaining constipation and postoperative obstruction symptoms after surgery in children with HD and ARM.
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spelling pubmed-97168592022-12-05 Quality of life outcomes in children after surgery for Hirschsprung disease and anorectal malformations: a systematic review and meta-analysis Oltean, Irina Hayawi, Lamia Larocca, Victoria Bijelić, Vid Beveridge, Emily Kaur, Manvinder Grandpierre, Viviane Kanyinda, Jane Nasr, Ahmed World J Pediatr Surg Review BACKGROUND: No systematic review and meta-analysis to date has examined multiple child and parent-reported social and physical quality of life (QoL) in pediatric populations affected by Hirschsprung’s disease (HD) and anorectal malformations (ARM). The objective of this systematic review is to quantitatively summarize the parent-reported and child-reported psychosocial and physical functioning scores of such children. METHODS: Records were sourced from the CENTRAL, EMBASE, and MEDLINE databases. Studies that reported child and parent reported QoL in children with HD and ARM, regardless of surgery intervention, versus children without HD and ARM, were included. The primary outcome was the psychosocial functioning scores, and the secondary outcomes were the presence of postoperative constipation, postoperative obstruction symptoms, fecal incontinence, and enterocolitis. A random effects meta-analysis was used. RESULTS: Twenty-three studies were included in the systematic review, with 11 studies included in the meta-analysis. Totally, 1678 total pediatric patients with HD and ARM underwent surgery vs 392 healthy controls. Pooled parent-reported standardized mean (SM) scores showed better social functioning after surgery (SM 91.79, 95% CI (80.3 to 103.3), I(2)=0). The pooled standardized mean difference (SMD) showed evidence for parent-reported incontinence but not for constipation in children with HD and ARM after surgery that had a lower mean QoL score compared with the normal population (SMD −1.24 (-1.79 to –0.69), I(2)=76% and SMD −0.45, 95% CI (−1.12 to 0.21), I(2)=75%). The pooled prevalence of child-reported constipation was 22% (95% CI (16% to 28%), I(2)=0%). The pooled prevalence of parent-reported postoperative obstruction symptoms was 61% (95% CI (41% to 81%), I(2)=41%). CONCLUSION: The results demonstrate better social functioning after surgery, lower QoL scores for incontinence versus controls, and remaining constipation and postoperative obstruction symptoms after surgery in children with HD and ARM. BMJ Publishing Group 2022-11-10 /pmc/articles/PMC9716859/ /pubmed/36474732 http://dx.doi.org/10.1136/wjps-2022-000447 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Review
Oltean, Irina
Hayawi, Lamia
Larocca, Victoria
Bijelić, Vid
Beveridge, Emily
Kaur, Manvinder
Grandpierre, Viviane
Kanyinda, Jane
Nasr, Ahmed
Quality of life outcomes in children after surgery for Hirschsprung disease and anorectal malformations: a systematic review and meta-analysis
title Quality of life outcomes in children after surgery for Hirschsprung disease and anorectal malformations: a systematic review and meta-analysis
title_full Quality of life outcomes in children after surgery for Hirschsprung disease and anorectal malformations: a systematic review and meta-analysis
title_fullStr Quality of life outcomes in children after surgery for Hirschsprung disease and anorectal malformations: a systematic review and meta-analysis
title_full_unstemmed Quality of life outcomes in children after surgery for Hirschsprung disease and anorectal malformations: a systematic review and meta-analysis
title_short Quality of life outcomes in children after surgery for Hirschsprung disease and anorectal malformations: a systematic review and meta-analysis
title_sort quality of life outcomes in children after surgery for hirschsprung disease and anorectal malformations: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716859/
https://www.ncbi.nlm.nih.gov/pubmed/36474732
http://dx.doi.org/10.1136/wjps-2022-000447
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