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Increased kidney disease mortality among people with AIDS versus the general population: a population-based cohort study in Italy, 2006–2018
OBJECTIVES: This study aimed to assess whether an excess mortality related to kidney and other urinary tract diseases exists among Italian people with AIDS (PWA), as compared with the general population without AIDS (non-PWA). DESIGN: Population-based, retrospective cohort study. SETTING AND PARTICI...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716863/ https://www.ncbi.nlm.nih.gov/pubmed/36456002 http://dx.doi.org/10.1136/bmjopen-2022-064970 |
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author | Taborelli, Martina Suligoi, Barbara Serraino, Diego Frova, Luisa Grande, Enrico Toffolutti, Federica Regine, Vincenza Pappagallo, Marilena Pugliese, Lucia Grippo, Francesco Zucchetto, Antonella |
author_facet | Taborelli, Martina Suligoi, Barbara Serraino, Diego Frova, Luisa Grande, Enrico Toffolutti, Federica Regine, Vincenza Pappagallo, Marilena Pugliese, Lucia Grippo, Francesco Zucchetto, Antonella |
author_sort | Taborelli, Martina |
collection | PubMed |
description | OBJECTIVES: This study aimed to assess whether an excess mortality related to kidney and other urinary tract diseases exists among Italian people with AIDS (PWA), as compared with the general population without AIDS (non-PWA). DESIGN: Population-based, retrospective cohort study. SETTING AND PARTICIPANTS: We conducted a nationwide study including 9481 Italian PWA, aged 15–74 years, reported to the National AIDS Registry between 2006 and 2018. METHODS: Vital status and causes of death were retrieved by record linkage with the National Register of Causes of Death up to 2018. Excess mortality for PWA versus non-PWA was estimated through sex-standardised and age-standardised mortality ratios (SMRs) with corresponding 95% CIs. RESULTS: Among 2613 deceased PWA, 262 (10.0%) reported at least one urinary tract disease at death, including 254 (9.7%) non-cancer diseases—mostly renal failures (225 cases, 8.6%)—and 9 cancers (0.3%). The overall SMR for non-cancer urinary tract diseases was 15.3 (95% CI 13.4 to 17.3) with statistically significant SMRs for acute (SMR=22.3, 95% CI 18.0 to 27.4), chronic (SMR=8.4, 95% CI 6.0 to 11.3), and unspecified renal failure (SMR=13.8, 95% CI 11.2 to 16.8). No statistically significant excess mortality was detected for urinary tract cancers (SMR=1.7, 95% CI 0.8 to 3.3). The SMRs were particularly elevated among PWA aged <50 years, injecting drug users, or those with the first HIV-positive test >6 months before AIDS diagnosis. CONCLUSIONS: The excess mortality related to non-cancer kidney and other urinary tract diseases reported among PWA highlights the importance of implementing the recommendation for screening, diagnosis and management of such conditions among this population. |
format | Online Article Text |
id | pubmed-9716863 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-97168632022-12-03 Increased kidney disease mortality among people with AIDS versus the general population: a population-based cohort study in Italy, 2006–2018 Taborelli, Martina Suligoi, Barbara Serraino, Diego Frova, Luisa Grande, Enrico Toffolutti, Federica Regine, Vincenza Pappagallo, Marilena Pugliese, Lucia Grippo, Francesco Zucchetto, Antonella BMJ Open Epidemiology OBJECTIVES: This study aimed to assess whether an excess mortality related to kidney and other urinary tract diseases exists among Italian people with AIDS (PWA), as compared with the general population without AIDS (non-PWA). DESIGN: Population-based, retrospective cohort study. SETTING AND PARTICIPANTS: We conducted a nationwide study including 9481 Italian PWA, aged 15–74 years, reported to the National AIDS Registry between 2006 and 2018. METHODS: Vital status and causes of death were retrieved by record linkage with the National Register of Causes of Death up to 2018. Excess mortality for PWA versus non-PWA was estimated through sex-standardised and age-standardised mortality ratios (SMRs) with corresponding 95% CIs. RESULTS: Among 2613 deceased PWA, 262 (10.0%) reported at least one urinary tract disease at death, including 254 (9.7%) non-cancer diseases—mostly renal failures (225 cases, 8.6%)—and 9 cancers (0.3%). The overall SMR for non-cancer urinary tract diseases was 15.3 (95% CI 13.4 to 17.3) with statistically significant SMRs for acute (SMR=22.3, 95% CI 18.0 to 27.4), chronic (SMR=8.4, 95% CI 6.0 to 11.3), and unspecified renal failure (SMR=13.8, 95% CI 11.2 to 16.8). No statistically significant excess mortality was detected for urinary tract cancers (SMR=1.7, 95% CI 0.8 to 3.3). The SMRs were particularly elevated among PWA aged <50 years, injecting drug users, or those with the first HIV-positive test >6 months before AIDS diagnosis. CONCLUSIONS: The excess mortality related to non-cancer kidney and other urinary tract diseases reported among PWA highlights the importance of implementing the recommendation for screening, diagnosis and management of such conditions among this population. BMJ Publishing Group 2022-12-01 /pmc/articles/PMC9716863/ /pubmed/36456002 http://dx.doi.org/10.1136/bmjopen-2022-064970 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Epidemiology Taborelli, Martina Suligoi, Barbara Serraino, Diego Frova, Luisa Grande, Enrico Toffolutti, Federica Regine, Vincenza Pappagallo, Marilena Pugliese, Lucia Grippo, Francesco Zucchetto, Antonella Increased kidney disease mortality among people with AIDS versus the general population: a population-based cohort study in Italy, 2006–2018 |
title | Increased kidney disease mortality among people with AIDS versus the general population: a population-based cohort study in Italy, 2006–2018 |
title_full | Increased kidney disease mortality among people with AIDS versus the general population: a population-based cohort study in Italy, 2006–2018 |
title_fullStr | Increased kidney disease mortality among people with AIDS versus the general population: a population-based cohort study in Italy, 2006–2018 |
title_full_unstemmed | Increased kidney disease mortality among people with AIDS versus the general population: a population-based cohort study in Italy, 2006–2018 |
title_short | Increased kidney disease mortality among people with AIDS versus the general population: a population-based cohort study in Italy, 2006–2018 |
title_sort | increased kidney disease mortality among people with aids versus the general population: a population-based cohort study in italy, 2006–2018 |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716863/ https://www.ncbi.nlm.nih.gov/pubmed/36456002 http://dx.doi.org/10.1136/bmjopen-2022-064970 |
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