Longitudinal Virological and Immunological Profile in a Case of Human Monkeypox Infection

In a male with severe proctitis, monkeypox virus DNA was detected in skin lesions, blood, the nasopharynx, and the rectum, underlying generalized viral spreading. Rectal involvement was still found when skin lesions disappeared. At this early stage, an increase of cytotoxic and activated T cells was...

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Autores principales: Zingaropoli, Maria Antonella, Parente, Alberico, Kertusha, Blerta, Campagna, Roberta, Tieghi, Tiziana, Garattini, Silvia, Marocco, Raffaella, Carraro, Anna, Tortellini, Eeva, Guardiani, Mariasilvia, Dominelli, Federica, Turriziani, Ombretta, Ciardi, Maria Rosa, Mastroianni, Claudio Maria, Del Borgo, Cosmo, Lichtner, Miriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716865/
https://www.ncbi.nlm.nih.gov/pubmed/36474633
http://dx.doi.org/10.1093/ofid/ofac569
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author Zingaropoli, Maria Antonella
Parente, Alberico
Kertusha, Blerta
Campagna, Roberta
Tieghi, Tiziana
Garattini, Silvia
Marocco, Raffaella
Carraro, Anna
Tortellini, Eeva
Guardiani, Mariasilvia
Dominelli, Federica
Turriziani, Ombretta
Ciardi, Maria Rosa
Mastroianni, Claudio Maria
Del Borgo, Cosmo
Lichtner, Miriam
author_facet Zingaropoli, Maria Antonella
Parente, Alberico
Kertusha, Blerta
Campagna, Roberta
Tieghi, Tiziana
Garattini, Silvia
Marocco, Raffaella
Carraro, Anna
Tortellini, Eeva
Guardiani, Mariasilvia
Dominelli, Federica
Turriziani, Ombretta
Ciardi, Maria Rosa
Mastroianni, Claudio Maria
Del Borgo, Cosmo
Lichtner, Miriam
author_sort Zingaropoli, Maria Antonella
collection PubMed
description In a male with severe proctitis, monkeypox virus DNA was detected in skin lesions, blood, the nasopharynx, and the rectum, underlying generalized viral spreading. Rectal involvement was still found when skin lesions disappeared. At this early stage, an increase of cytotoxic and activated T cells was observed, while a reduction in CD56dimCD57+ NK cells compared with recovery time point was observed.
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spelling pubmed-97168652022-12-05 Longitudinal Virological and Immunological Profile in a Case of Human Monkeypox Infection Zingaropoli, Maria Antonella Parente, Alberico Kertusha, Blerta Campagna, Roberta Tieghi, Tiziana Garattini, Silvia Marocco, Raffaella Carraro, Anna Tortellini, Eeva Guardiani, Mariasilvia Dominelli, Federica Turriziani, Ombretta Ciardi, Maria Rosa Mastroianni, Claudio Maria Del Borgo, Cosmo Lichtner, Miriam Open Forum Infect Dis Brief Report In a male with severe proctitis, monkeypox virus DNA was detected in skin lesions, blood, the nasopharynx, and the rectum, underlying generalized viral spreading. Rectal involvement was still found when skin lesions disappeared. At this early stage, an increase of cytotoxic and activated T cells was observed, while a reduction in CD56dimCD57+ NK cells compared with recovery time point was observed. Oxford University Press 2022-11-01 /pmc/articles/PMC9716865/ /pubmed/36474633 http://dx.doi.org/10.1093/ofid/ofac569 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Zingaropoli, Maria Antonella
Parente, Alberico
Kertusha, Blerta
Campagna, Roberta
Tieghi, Tiziana
Garattini, Silvia
Marocco, Raffaella
Carraro, Anna
Tortellini, Eeva
Guardiani, Mariasilvia
Dominelli, Federica
Turriziani, Ombretta
Ciardi, Maria Rosa
Mastroianni, Claudio Maria
Del Borgo, Cosmo
Lichtner, Miriam
Longitudinal Virological and Immunological Profile in a Case of Human Monkeypox Infection
title Longitudinal Virological and Immunological Profile in a Case of Human Monkeypox Infection
title_full Longitudinal Virological and Immunological Profile in a Case of Human Monkeypox Infection
title_fullStr Longitudinal Virological and Immunological Profile in a Case of Human Monkeypox Infection
title_full_unstemmed Longitudinal Virological and Immunological Profile in a Case of Human Monkeypox Infection
title_short Longitudinal Virological and Immunological Profile in a Case of Human Monkeypox Infection
title_sort longitudinal virological and immunological profile in a case of human monkeypox infection
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716865/
https://www.ncbi.nlm.nih.gov/pubmed/36474633
http://dx.doi.org/10.1093/ofid/ofac569
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