Evaluation of the Effect of Eslicarbazepine Acetate on the Pharmacokinetics of Perampanel in Rats by Isotope-Dilution-UHPLC-MS/MS

PURPOSE: The present study aimed to establish and validate an isotope-dilution-UHPLC-MS/MS method for the determination of perampanel (PER) concentration and investigate the effect of eslicarbazepine acetate (ESL) on the pharmacokinetics of PER in rats. METHODS: The rats were randomly divided into t...

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Detalles Bibliográficos
Autores principales: Liu, Ping, An, Jing, Wu, Huizhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716937/
https://www.ncbi.nlm.nih.gov/pubmed/36465267
http://dx.doi.org/10.2147/DDDT.S392934

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716937/
https://www.ncbi.nlm.nih.gov/pubmed/36465267
http://dx.doi.org/10.2147/DDDT.S392934

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