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Comparison of general anesthesia and continuous intravenous sedation for electrochemotherapy of head and neck skin lesions
BACKGROUND: Electrochemotherapy of cutaneous tumor nodules requires local or general anesthesia. For multiple and larger nodules, general anesthesia is recommended by standard operating procedures. The choice of general anesthesia is at the discretion of the treating center. Continuous intravenous s...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9717680/ https://www.ncbi.nlm.nih.gov/pubmed/36465339 http://dx.doi.org/10.3389/fonc.2022.1011721 |
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author | Benedik, Janez Ogorevc, Barbara Brezar, Simona Kranjc Cemazar, Maja Sersa, Gregor Groselj, Ales |
author_facet | Benedik, Janez Ogorevc, Barbara Brezar, Simona Kranjc Cemazar, Maja Sersa, Gregor Groselj, Ales |
author_sort | Benedik, Janez |
collection | PubMed |
description | BACKGROUND: Electrochemotherapy of cutaneous tumor nodules requires local or general anesthesia. For multiple and larger nodules, general anesthesia is recommended by standard operating procedures. The choice of general anesthesia is at the discretion of the treating center. Continuous intravenous sedation is also an option. Our study aimed to elucidate the tolerability, safety and possible advantages of continuous intravenous sedation in comparison to general anesthesia in patients undergoing electrochemotherapy. PATIENTS AND METHODS: In the prospective study, 27 patients undergoing electrochemotherapy were either under general anesthesia or under continuous intravenous sedation. Evaluated were different endpoints, such as feasibility and safety, duration of anesthesia and compliance with the patients. RESULTS: Ten patients were treated under general anesthesia, and 17 patients were under continuous intravenous sedation. The comparison of the approaches indicated that continuous intravenous sedation required a lower overall dosage of propofol, a shorter duration of anesthesia, a shorter time to reach an Aldrete score >8, and greater satisfaction of the patients with the procedure compared to general anesthesia. CONCLUSION: The results indicate the feasibility and safety of continuous intravenous sedation for patients undergoing electrochemotherapy of cutaneous tumor nodules. This proved the preferred choice of anesthesia due to its shorter duration and better compliance with the patients compared to general anesthesia. |
format | Online Article Text |
id | pubmed-9717680 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97176802022-12-03 Comparison of general anesthesia and continuous intravenous sedation for electrochemotherapy of head and neck skin lesions Benedik, Janez Ogorevc, Barbara Brezar, Simona Kranjc Cemazar, Maja Sersa, Gregor Groselj, Ales Front Oncol Oncology BACKGROUND: Electrochemotherapy of cutaneous tumor nodules requires local or general anesthesia. For multiple and larger nodules, general anesthesia is recommended by standard operating procedures. The choice of general anesthesia is at the discretion of the treating center. Continuous intravenous sedation is also an option. Our study aimed to elucidate the tolerability, safety and possible advantages of continuous intravenous sedation in comparison to general anesthesia in patients undergoing electrochemotherapy. PATIENTS AND METHODS: In the prospective study, 27 patients undergoing electrochemotherapy were either under general anesthesia or under continuous intravenous sedation. Evaluated were different endpoints, such as feasibility and safety, duration of anesthesia and compliance with the patients. RESULTS: Ten patients were treated under general anesthesia, and 17 patients were under continuous intravenous sedation. The comparison of the approaches indicated that continuous intravenous sedation required a lower overall dosage of propofol, a shorter duration of anesthesia, a shorter time to reach an Aldrete score >8, and greater satisfaction of the patients with the procedure compared to general anesthesia. CONCLUSION: The results indicate the feasibility and safety of continuous intravenous sedation for patients undergoing electrochemotherapy of cutaneous tumor nodules. This proved the preferred choice of anesthesia due to its shorter duration and better compliance with the patients compared to general anesthesia. Frontiers Media S.A. 2022-11-18 /pmc/articles/PMC9717680/ /pubmed/36465339 http://dx.doi.org/10.3389/fonc.2022.1011721 Text en Copyright © 2022 Benedik, Ogorevc, Brezar, Cemazar, Sersa and Groselj https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Benedik, Janez Ogorevc, Barbara Brezar, Simona Kranjc Cemazar, Maja Sersa, Gregor Groselj, Ales Comparison of general anesthesia and continuous intravenous sedation for electrochemotherapy of head and neck skin lesions |
title | Comparison of general anesthesia and continuous intravenous sedation for electrochemotherapy of head and neck skin lesions |
title_full | Comparison of general anesthesia and continuous intravenous sedation for electrochemotherapy of head and neck skin lesions |
title_fullStr | Comparison of general anesthesia and continuous intravenous sedation for electrochemotherapy of head and neck skin lesions |
title_full_unstemmed | Comparison of general anesthesia and continuous intravenous sedation for electrochemotherapy of head and neck skin lesions |
title_short | Comparison of general anesthesia and continuous intravenous sedation for electrochemotherapy of head and neck skin lesions |
title_sort | comparison of general anesthesia and continuous intravenous sedation for electrochemotherapy of head and neck skin lesions |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9717680/ https://www.ncbi.nlm.nih.gov/pubmed/36465339 http://dx.doi.org/10.3389/fonc.2022.1011721 |
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