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Germany’s Burden of Disease of Bloodstream Infections Due to Vancomycin-Resistant Enterococcus faecium between 2015–2020

In Germany, there is an increasing amount of vancomycin-resistant Enterococcus faecium (VREfm) isolates in bloodstream infections (BSIs); however, estimates on recent incidences and disease burden are missing. We aim to estimate the incidence and calculate the annual disease burden in disease-adjust...

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Autores principales: Brinkwirth, Simon, Martins, Sofie, Ayobami, Olaniyi, Feig, Marcel, Noll, Ines, Zacher, Benedikt, Eckmanns, Tim, Werner, Guido, Willrich, Niklas, Haller, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9717732/
https://www.ncbi.nlm.nih.gov/pubmed/36422343
http://dx.doi.org/10.3390/microorganisms10112273
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author Brinkwirth, Simon
Martins, Sofie
Ayobami, Olaniyi
Feig, Marcel
Noll, Ines
Zacher, Benedikt
Eckmanns, Tim
Werner, Guido
Willrich, Niklas
Haller, Sebastian
author_facet Brinkwirth, Simon
Martins, Sofie
Ayobami, Olaniyi
Feig, Marcel
Noll, Ines
Zacher, Benedikt
Eckmanns, Tim
Werner, Guido
Willrich, Niklas
Haller, Sebastian
author_sort Brinkwirth, Simon
collection PubMed
description In Germany, there is an increasing amount of vancomycin-resistant Enterococcus faecium (VREfm) isolates in bloodstream infections (BSIs); however, estimates on recent incidences and disease burden are missing. We aim to estimate the incidence and calculate the annual disease burden in disease-adjusted life years (DALYs) for BSIs due to VREfm in Germany between 2015 and 2020 to support informed decision-making in the field of antimicrobial resistance (AMR). We used the Antibiotic Resistance Surveillance (ARS) system data to obtain incidence estimates. The estimated incidences were used in the Burden of Communicable Disease in Europe (BCoDE) toolkit to calculate the attributable DALYs. A total of 3417 VREfm blood culture-positive isolates were observed within ARS. The estimated incidence of VREfm-BSIs per 100,000 inhabitants increased from 1.4 (95% Uncertainty Interval [UI]: 0.8–1.9) in 2015 to 2.9 (95% UI: 2.4–3.3) in 2020. The estimated burden, expressed in DALYs per 100,000 inhabitants, increased from 8.5 (95% UI: 7.3–9.7; YLD = 0.9, YLL = 7.6) in 2015 to 15.6 (95% UI: 14.6–16.6; YLD = 1.6, YLL = 14) in 2020. The most affected groups within the observed period are the 65–69-year-old males with 262.9 DALYs per 100,000 inhabitants, and in the younger age groups (<30 years), the under-one-year-old with 43.1 DALYs per 100,000 inhabitants and 34.5 DALYs for male and female, respectively. The increasing DALYs of BSIs due to VREfm require targeted prevention and control measures to address their unequal distribution across gender and age, especially for older hospitalized patients, neonates, and infants in Germany.
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spelling pubmed-97177322022-12-03 Germany’s Burden of Disease of Bloodstream Infections Due to Vancomycin-Resistant Enterococcus faecium between 2015–2020 Brinkwirth, Simon Martins, Sofie Ayobami, Olaniyi Feig, Marcel Noll, Ines Zacher, Benedikt Eckmanns, Tim Werner, Guido Willrich, Niklas Haller, Sebastian Microorganisms Article In Germany, there is an increasing amount of vancomycin-resistant Enterococcus faecium (VREfm) isolates in bloodstream infections (BSIs); however, estimates on recent incidences and disease burden are missing. We aim to estimate the incidence and calculate the annual disease burden in disease-adjusted life years (DALYs) for BSIs due to VREfm in Germany between 2015 and 2020 to support informed decision-making in the field of antimicrobial resistance (AMR). We used the Antibiotic Resistance Surveillance (ARS) system data to obtain incidence estimates. The estimated incidences were used in the Burden of Communicable Disease in Europe (BCoDE) toolkit to calculate the attributable DALYs. A total of 3417 VREfm blood culture-positive isolates were observed within ARS. The estimated incidence of VREfm-BSIs per 100,000 inhabitants increased from 1.4 (95% Uncertainty Interval [UI]: 0.8–1.9) in 2015 to 2.9 (95% UI: 2.4–3.3) in 2020. The estimated burden, expressed in DALYs per 100,000 inhabitants, increased from 8.5 (95% UI: 7.3–9.7; YLD = 0.9, YLL = 7.6) in 2015 to 15.6 (95% UI: 14.6–16.6; YLD = 1.6, YLL = 14) in 2020. The most affected groups within the observed period are the 65–69-year-old males with 262.9 DALYs per 100,000 inhabitants, and in the younger age groups (<30 years), the under-one-year-old with 43.1 DALYs per 100,000 inhabitants and 34.5 DALYs for male and female, respectively. The increasing DALYs of BSIs due to VREfm require targeted prevention and control measures to address their unequal distribution across gender and age, especially for older hospitalized patients, neonates, and infants in Germany. MDPI 2022-11-16 /pmc/articles/PMC9717732/ /pubmed/36422343 http://dx.doi.org/10.3390/microorganisms10112273 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Brinkwirth, Simon
Martins, Sofie
Ayobami, Olaniyi
Feig, Marcel
Noll, Ines
Zacher, Benedikt
Eckmanns, Tim
Werner, Guido
Willrich, Niklas
Haller, Sebastian
Germany’s Burden of Disease of Bloodstream Infections Due to Vancomycin-Resistant Enterococcus faecium between 2015–2020
title Germany’s Burden of Disease of Bloodstream Infections Due to Vancomycin-Resistant Enterococcus faecium between 2015–2020
title_full Germany’s Burden of Disease of Bloodstream Infections Due to Vancomycin-Resistant Enterococcus faecium between 2015–2020
title_fullStr Germany’s Burden of Disease of Bloodstream Infections Due to Vancomycin-Resistant Enterococcus faecium between 2015–2020
title_full_unstemmed Germany’s Burden of Disease of Bloodstream Infections Due to Vancomycin-Resistant Enterococcus faecium between 2015–2020
title_short Germany’s Burden of Disease of Bloodstream Infections Due to Vancomycin-Resistant Enterococcus faecium between 2015–2020
title_sort germany’s burden of disease of bloodstream infections due to vancomycin-resistant enterococcus faecium between 2015–2020
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9717732/
https://www.ncbi.nlm.nih.gov/pubmed/36422343
http://dx.doi.org/10.3390/microorganisms10112273
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