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The role of metabolomics in precision medicine of osteoarthritis: How far are we?
OBJECTIVES: A narrative review on recent published studies of metabolomics in osteoarthritis (OA) with the focus on how the metabolomic findings help stratify OA patients in precision medicine. DESIGN: A narrative review based on selected population-based metabolomics studies in OA. RESULTS: PubMed...
Autor principal: | |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718119/ https://www.ncbi.nlm.nih.gov/pubmed/36474767 http://dx.doi.org/10.1016/j.ocarto.2021.100170 |
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author | Zhai, Guangju |
author_facet | Zhai, Guangju |
author_sort | Zhai, Guangju |
collection | PubMed |
description | OBJECTIVES: A narrative review on recent published studies of metabolomics in osteoarthritis (OA) with the focus on how the metabolomic findings help stratify OA patients in precision medicine. DESIGN: A narrative review based on selected population-based metabolomics studies in OA. RESULTS: PubMed search resulted in a total 139 articles on metabolomics of OA. One hundred and seven articles were excluded because they were either reviews, in vitro studies, animal models. Thirty-two population-based metabolomic studies using either plasma/serum, synovial fluid, cartilage, or subchondral bone samples were reviewed. The most reported metabolic pathways to be involved in OA included energy metabolic pathways, arginine and proline metabolism, taurine and hypotaurine metabolism, and glycerophospholipid metabolism. CONCLUSIONS: While metabolomics of OA research is still in its infancy, the published data showed that metabolomics is a promising tool to help better understanding of pathogenesis of OA, classify OA patients into different endotypes, and develop precision medicine tools for OA management. |
format | Online Article Text |
id | pubmed-9718119 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-97181192022-12-05 The role of metabolomics in precision medicine of osteoarthritis: How far are we? Zhai, Guangju Osteoarthr Cartil Open Virtual Special Issue on: Omics Phenotyping; Edited by Mohit Kapoor, AliMobasheri, Shabana Amanda Ali and Annemarie Lang OBJECTIVES: A narrative review on recent published studies of metabolomics in osteoarthritis (OA) with the focus on how the metabolomic findings help stratify OA patients in precision medicine. DESIGN: A narrative review based on selected population-based metabolomics studies in OA. RESULTS: PubMed search resulted in a total 139 articles on metabolomics of OA. One hundred and seven articles were excluded because they were either reviews, in vitro studies, animal models. Thirty-two population-based metabolomic studies using either plasma/serum, synovial fluid, cartilage, or subchondral bone samples were reviewed. The most reported metabolic pathways to be involved in OA included energy metabolic pathways, arginine and proline metabolism, taurine and hypotaurine metabolism, and glycerophospholipid metabolism. CONCLUSIONS: While metabolomics of OA research is still in its infancy, the published data showed that metabolomics is a promising tool to help better understanding of pathogenesis of OA, classify OA patients into different endotypes, and develop precision medicine tools for OA management. Elsevier 2021-04-30 /pmc/articles/PMC9718119/ /pubmed/36474767 http://dx.doi.org/10.1016/j.ocarto.2021.100170 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Virtual Special Issue on: Omics Phenotyping; Edited by Mohit Kapoor, AliMobasheri, Shabana Amanda Ali and Annemarie Lang Zhai, Guangju The role of metabolomics in precision medicine of osteoarthritis: How far are we? |
title | The role of metabolomics in precision medicine of osteoarthritis: How far are we? |
title_full | The role of metabolomics in precision medicine of osteoarthritis: How far are we? |
title_fullStr | The role of metabolomics in precision medicine of osteoarthritis: How far are we? |
title_full_unstemmed | The role of metabolomics in precision medicine of osteoarthritis: How far are we? |
title_short | The role of metabolomics in precision medicine of osteoarthritis: How far are we? |
title_sort | role of metabolomics in precision medicine of osteoarthritis: how far are we? |
topic | Virtual Special Issue on: Omics Phenotyping; Edited by Mohit Kapoor, AliMobasheri, Shabana Amanda Ali and Annemarie Lang |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718119/ https://www.ncbi.nlm.nih.gov/pubmed/36474767 http://dx.doi.org/10.1016/j.ocarto.2021.100170 |
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