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Development of a highly sensitive chemiluminescence immunoassay for quantification of aggrecanase-generated ARGS aggrecan fragments in serum

OBJECTIVE: Cartilage degradation is a hallmark of osteoarthritis (OA). Aggrecan, a major proteoglycan of articular cartilage extracellular matrix (ECM), is degraded by ADAMTS-5 resulting in the release of ARGS-G2 fragments to synovial fluid and circulation. The aim was to quantify ARGS-G2 in the ser...

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Detalles Bibliográficos
Autores principales:	He, Yi, Jensen, Kamilla E., Siebuhr, Anne Sofie, Karsdal, Morten A., Larkin, Jonathan, Bay-Jensen, Anne C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	ORIGINAL PAPER
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718149/ https://www.ncbi.nlm.nih.gov/pubmed/36474987 http://dx.doi.org/10.1016/j.ocarto.2021.100162

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