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Framework for modulating ambulatory load in the context of in vivo mechanosensitivity of articular cartilage
OBJECTIVE: Different stress modalities have been used to provoke a load induced mechanoresponse in blood markers of articular cartilages. The challenge in in vivo experiments is to alter specific loading characteristics. Here, we aimed to develop a load modification framework that changes ambulatory...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718181/ https://www.ncbi.nlm.nih.gov/pubmed/36474889 http://dx.doi.org/10.1016/j.ocarto.2020.100108 |
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author | Herger, Simon Nüesch, Corina Liphardt, Anna-Maria Egloff, Christian Mündermann, Annegret |
author_facet | Herger, Simon Nüesch, Corina Liphardt, Anna-Maria Egloff, Christian Mündermann, Annegret |
author_sort | Herger, Simon |
collection | PubMed |
description | OBJECTIVE: Different stress modalities have been used to provoke a load induced mechanoresponse in blood markers of articular cartilages. The challenge in in vivo experiments is to alter specific loading characteristics. Here, we aimed to develop a load modification framework that changes ambulatory load magnitude without changing load frequency or joint kinematics. DESIGN: Spatiotemporal parameters, sagittal joint kinematics and vertical ground reaction force (vGRF) of 24 healthy participants were recorded while walking with reduced (80%), normal (100%) and increased (120%) bodyweight (BW) on three separate test days in a block randomized cross-over design. The reduced and increased load conditions were compared to the normal load condition using paired sample t-tests for spatiotemporal parameters and statistical parametric mapping for vGRF and joint kinematics. RESULTS: Load modification resulted in measured vGRF differences of −19.5%BW (reduced) and +16.8%BW (increased). Spatiotemporal parameters with reduced and increased load did not differ from normal load except of a shorter stance time under reduced load (−21 ms). Joint kinematics for both conditions did not differ from normal load except of decreased ankle dorsiflexion (maximum −5.9°) and increased knee flexion (maximum +6.5°) for the reduced load condition during pre-swing when the support limb is already unloaded. CONCLUSION: Overall, we did not observe relevant differences in spatiotemporal parameters or joint kinematics between loading conditions. Mean absolute joint angle deviations below 4.1° demonstrate that the proposed load modification framework changes ambulatory load magnitude without changing load frequency or joint kinematics. |
format | Online Article Text |
id | pubmed-9718181 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-97181812022-12-05 Framework for modulating ambulatory load in the context of in vivo mechanosensitivity of articular cartilage Herger, Simon Nüesch, Corina Liphardt, Anna-Maria Egloff, Christian Mündermann, Annegret Osteoarthr Cartil Open ORIGINAL PAPER OBJECTIVE: Different stress modalities have been used to provoke a load induced mechanoresponse in blood markers of articular cartilages. The challenge in in vivo experiments is to alter specific loading characteristics. Here, we aimed to develop a load modification framework that changes ambulatory load magnitude without changing load frequency or joint kinematics. DESIGN: Spatiotemporal parameters, sagittal joint kinematics and vertical ground reaction force (vGRF) of 24 healthy participants were recorded while walking with reduced (80%), normal (100%) and increased (120%) bodyweight (BW) on three separate test days in a block randomized cross-over design. The reduced and increased load conditions were compared to the normal load condition using paired sample t-tests for spatiotemporal parameters and statistical parametric mapping for vGRF and joint kinematics. RESULTS: Load modification resulted in measured vGRF differences of −19.5%BW (reduced) and +16.8%BW (increased). Spatiotemporal parameters with reduced and increased load did not differ from normal load except of a shorter stance time under reduced load (−21 ms). Joint kinematics for both conditions did not differ from normal load except of decreased ankle dorsiflexion (maximum −5.9°) and increased knee flexion (maximum +6.5°) for the reduced load condition during pre-swing when the support limb is already unloaded. CONCLUSION: Overall, we did not observe relevant differences in spatiotemporal parameters or joint kinematics between loading conditions. Mean absolute joint angle deviations below 4.1° demonstrate that the proposed load modification framework changes ambulatory load magnitude without changing load frequency or joint kinematics. Elsevier 2020-10-09 /pmc/articles/PMC9718181/ /pubmed/36474889 http://dx.doi.org/10.1016/j.ocarto.2020.100108 Text en © 2020 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | ORIGINAL PAPER Herger, Simon Nüesch, Corina Liphardt, Anna-Maria Egloff, Christian Mündermann, Annegret Framework for modulating ambulatory load in the context of in vivo mechanosensitivity of articular cartilage |
title | Framework for modulating ambulatory load in the context of in vivo mechanosensitivity of articular cartilage |
title_full | Framework for modulating ambulatory load in the context of in vivo mechanosensitivity of articular cartilage |
title_fullStr | Framework for modulating ambulatory load in the context of in vivo mechanosensitivity of articular cartilage |
title_full_unstemmed | Framework for modulating ambulatory load in the context of in vivo mechanosensitivity of articular cartilage |
title_short | Framework for modulating ambulatory load in the context of in vivo mechanosensitivity of articular cartilage |
title_sort | framework for modulating ambulatory load in the context of in vivo mechanosensitivity of articular cartilage |
topic | ORIGINAL PAPER |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718181/ https://www.ncbi.nlm.nih.gov/pubmed/36474889 http://dx.doi.org/10.1016/j.ocarto.2020.100108 |
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