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Predominant lifetime occupation and associations with painful and structural knee osteoarthritis: An international participant-level cohort collaboration

OBJECTIVE: With adults working to older ages, occupation is an important, yet less modifiable domain of physical activity to consider in the risk of knee osteoarthritis (OA). This study aimed to investigate the association between predominant lifetime occupation and prevalent knee OA. DESIGN: Partic...

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Autores principales: Parsons, Camille M., Gates, Lucy S., Perry, Thomas, Nevitt, Michael, Felson, David, Sanchez-Santos, Maria T., Jones, Graeme, Golightly, Yvonne M., Allen, Kelli D., Callahan, Leigh F., White, Daniel K., Walker-Bone, Karen, Cooper, Cyrus, Arden, Nigel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718216/
https://www.ncbi.nlm.nih.gov/pubmed/36474872
http://dx.doi.org/10.1016/j.ocarto.2020.100085
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author Parsons, Camille M.
Gates, Lucy S.
Perry, Thomas
Nevitt, Michael
Felson, David
Sanchez-Santos, Maria T.
Jones, Graeme
Golightly, Yvonne M.
Allen, Kelli D.
Callahan, Leigh F.
White, Daniel K.
Walker-Bone, Karen
Cooper, Cyrus
Arden, Nigel K.
author_facet Parsons, Camille M.
Gates, Lucy S.
Perry, Thomas
Nevitt, Michael
Felson, David
Sanchez-Santos, Maria T.
Jones, Graeme
Golightly, Yvonne M.
Allen, Kelli D.
Callahan, Leigh F.
White, Daniel K.
Walker-Bone, Karen
Cooper, Cyrus
Arden, Nigel K.
author_sort Parsons, Camille M.
collection PubMed
description OBJECTIVE: With adults working to older ages, occupation is an important, yet less modifiable domain of physical activity to consider in the risk of knee osteoarthritis (OA). This study aimed to investigate the association between predominant lifetime occupation and prevalent knee OA. DESIGN: Participant-level data were used from five international community-based cohorts: Johnston County Osteoarthritis Project, the Hertfordshire Cohort Study, the Multicenter Osteoarthritis Study, the Tasmanian Cohort Study and Framingham Osteoarthritis Study. Self-reported predominant occupation was categorized into sedentary, light, light manual and heavy manual levels. Cross-sectional associations between predominant lifetime occupation and knee OA outcomes including prevalence of radiographic knee OA (RKOA), symptomatic RKOA and knee pain, were assessed using logistic regression, accounting for cohort clustering. RESULTS: Data for 7391 participants were included. 24.7% reported sedentary lifetime occupation, 30.0% light, 35.9% light manual and 9.4% heavy manual. 43.3% presented with RKOA, 52.1% with knee pain and 29.0% with symptomatic RKOA. There was over a two-fold increase in the odds of having RKOA, knee pain and symptomatic RKOA in those whose with heavy manual compared to sedentary occupations ((odds ratio (OR): 2.14; 95% confidence interval (CI): 1.79, 2.58), (OR: 2.19; 95% CI: 1.78, 2.70), (OR: 2.41; 95% CI: 1.94, 2.99) respectively). CONCLUSION: This large international multi-cohort study demonstrated an association of heavy manual work with RKOA, symptomatic RKOA and knee pain. Measures that protect workers and are designed to reduce heavy manual related activities remain a priority to reduce the risk of knee OA.
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spelling pubmed-97182162022-12-05 Predominant lifetime occupation and associations with painful and structural knee osteoarthritis: An international participant-level cohort collaboration Parsons, Camille M. Gates, Lucy S. Perry, Thomas Nevitt, Michael Felson, David Sanchez-Santos, Maria T. Jones, Graeme Golightly, Yvonne M. Allen, Kelli D. Callahan, Leigh F. White, Daniel K. Walker-Bone, Karen Cooper, Cyrus Arden, Nigel K. Osteoarthr Cartil Open ORIGINAL PAPER OBJECTIVE: With adults working to older ages, occupation is an important, yet less modifiable domain of physical activity to consider in the risk of knee osteoarthritis (OA). This study aimed to investigate the association between predominant lifetime occupation and prevalent knee OA. DESIGN: Participant-level data were used from five international community-based cohorts: Johnston County Osteoarthritis Project, the Hertfordshire Cohort Study, the Multicenter Osteoarthritis Study, the Tasmanian Cohort Study and Framingham Osteoarthritis Study. Self-reported predominant occupation was categorized into sedentary, light, light manual and heavy manual levels. Cross-sectional associations between predominant lifetime occupation and knee OA outcomes including prevalence of radiographic knee OA (RKOA), symptomatic RKOA and knee pain, were assessed using logistic regression, accounting for cohort clustering. RESULTS: Data for 7391 participants were included. 24.7% reported sedentary lifetime occupation, 30.0% light, 35.9% light manual and 9.4% heavy manual. 43.3% presented with RKOA, 52.1% with knee pain and 29.0% with symptomatic RKOA. There was over a two-fold increase in the odds of having RKOA, knee pain and symptomatic RKOA in those whose with heavy manual compared to sedentary occupations ((odds ratio (OR): 2.14; 95% confidence interval (CI): 1.79, 2.58), (OR: 2.19; 95% CI: 1.78, 2.70), (OR: 2.41; 95% CI: 1.94, 2.99) respectively). CONCLUSION: This large international multi-cohort study demonstrated an association of heavy manual work with RKOA, symptomatic RKOA and knee pain. Measures that protect workers and are designed to reduce heavy manual related activities remain a priority to reduce the risk of knee OA. Elsevier 2020-06-25 /pmc/articles/PMC9718216/ /pubmed/36474872 http://dx.doi.org/10.1016/j.ocarto.2020.100085 Text en © 2020 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle ORIGINAL PAPER
Parsons, Camille M.
Gates, Lucy S.
Perry, Thomas
Nevitt, Michael
Felson, David
Sanchez-Santos, Maria T.
Jones, Graeme
Golightly, Yvonne M.
Allen, Kelli D.
Callahan, Leigh F.
White, Daniel K.
Walker-Bone, Karen
Cooper, Cyrus
Arden, Nigel K.
Predominant lifetime occupation and associations with painful and structural knee osteoarthritis: An international participant-level cohort collaboration
title Predominant lifetime occupation and associations with painful and structural knee osteoarthritis: An international participant-level cohort collaboration
title_full Predominant lifetime occupation and associations with painful and structural knee osteoarthritis: An international participant-level cohort collaboration
title_fullStr Predominant lifetime occupation and associations with painful and structural knee osteoarthritis: An international participant-level cohort collaboration
title_full_unstemmed Predominant lifetime occupation and associations with painful and structural knee osteoarthritis: An international participant-level cohort collaboration
title_short Predominant lifetime occupation and associations with painful and structural knee osteoarthritis: An international participant-level cohort collaboration
title_sort predominant lifetime occupation and associations with painful and structural knee osteoarthritis: an international participant-level cohort collaboration
topic ORIGINAL PAPER
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718216/
https://www.ncbi.nlm.nih.gov/pubmed/36474872
http://dx.doi.org/10.1016/j.ocarto.2020.100085
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