Cargando…
Identifying small molecules for protecting chondrocyte function and matrix integrity after controlled compressive injury
OBJECTIVE: Articular cartilage injury is central for the development of post-traumatic osteoarthritis (PTOA). With few disease-modifying therapies successful at offsetting progressive osteoarthritis (OA), our goal is to use a high throughput screening platform of cartilage injury to identify novel c...
Autores principales: | Al Jundi, Saleh, Martinez, Jerahme R., Cresta, Jake, Yousefi, Farzad, DeSantis, Gabriel, Thoonkuzhy, Matthew, Rabut, Emilie, Mohanraj, Bhavana, Mauck, Robert L., Dodge, George R. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718264/ https://www.ncbi.nlm.nih.gov/pubmed/36474951 http://dx.doi.org/10.1016/j.ocarto.2022.100289 |
Ejemplares similares
-
IL-1ra delivered from poly(lactic-co-glycolic acid) microspheres attenuates IL-1β-mediated degradation of nucleus pulposus in vitro
por: Gorth, Deborah J, et al.
Publicado: (2012) -
Spatial distribution of type II collagen gene expression in the mouse intervertebral disc
por: Wei, Yulong, et al.
Publicado: (2019) -
Effects of mechanical stress on chondrocyte phenotype and chondrocyte extracellular matrix expression
por: Liu, Qiang, et al.
Publicado: (2016) -
Oxygen tension modulates the effects of TNFα in compressed chondrocytes
por: Tilwani, R. K., et al.
Publicado: (2016) -
Perturbation of adhesion molecule-mediated chondrocyte-matrix interactions by 4-hydroxynonenal binding: implication in osteoarthritis pathogenesis
por: El-Bikai, Rana, et al.
Publicado: (2010)