Blocking Caspase-1/Gsdmd and Caspase-3/-8/Gsdme pyroptotic pathways rescues silicosis in mice

Millions of patients suffer from silicosis, but it remains an uncurable disease due to its unclear pathogenic mechanisms. Though the Nlrp3 inflammasome is involved in silicosis pathogenesis, inhibition of its classic downstream factors, Caspase-1 and Gsdmd, fails to block pyroptosis and cytokine rel...

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Detalles Bibliográficos
Autores principales: Kang, Lulu, Dai, Jinghong, Wang, Yufang, Shi, Peiliang, Zou, Yujie, Pei, Jingwen, Tian, Yaqiong, Zhang, Ji, Buranasudja, Visarut Codey, Chen, Jingyu, Cai, Hourong, Gao, Xiang, Lin, Zhaoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718385/
https://www.ncbi.nlm.nih.gov/pubmed/36459518
http://dx.doi.org/10.1371/journal.pgen.1010515

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