ZHX2 in health and disease

As a transcriptional factor and the negative regulator of alpha fetal protein (AFP), Zinc fingers and homeoboxes 2 (ZHX2) has a well-established role in protection against hepatocellular carcinoma (HCC). However, recent studies have suggested ZHX2 as an oncogene in clear cell renal cell carcinoma (c...

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Detalles Bibliográficos
Autores principales: Li, Na, Wu, Zhuanchang, Ma, Chunhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718504/
https://www.ncbi.nlm.nih.gov/pubmed/36465389
http://dx.doi.org/10.3389/fonc.2022.1038890
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author Li, Na
Wu, Zhuanchang
Ma, Chunhong
author_facet Li, Na
Wu, Zhuanchang
Ma, Chunhong
author_sort Li, Na
collection PubMed
description As a transcriptional factor and the negative regulator of alpha fetal protein (AFP), Zinc fingers and homeoboxes 2 (ZHX2) has a well-established role in protection against hepatocellular carcinoma (HCC). However, recent studies have suggested ZHX2 as an oncogene in clear cell renal cell carcinoma (ccRCC) and triple-negative breast cancer (TNBC). Moreover, mounting evidence has illustrated a much broader role of ZHX2 in multiple cellular processes, including cell proliferation, cell differentiation, lipid metabolism, and immunoregulation. This comprehensive review emphasizes the role of ZHX2 in health and diseases which have been more recently uncovered.
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spelling pubmed-97185042022-12-03 ZHX2 in health and disease Li, Na Wu, Zhuanchang Ma, Chunhong Front Oncol Oncology As a transcriptional factor and the negative regulator of alpha fetal protein (AFP), Zinc fingers and homeoboxes 2 (ZHX2) has a well-established role in protection against hepatocellular carcinoma (HCC). However, recent studies have suggested ZHX2 as an oncogene in clear cell renal cell carcinoma (ccRCC) and triple-negative breast cancer (TNBC). Moreover, mounting evidence has illustrated a much broader role of ZHX2 in multiple cellular processes, including cell proliferation, cell differentiation, lipid metabolism, and immunoregulation. This comprehensive review emphasizes the role of ZHX2 in health and diseases which have been more recently uncovered. Frontiers Media S.A. 2022-11-18 /pmc/articles/PMC9718504/ /pubmed/36465389 http://dx.doi.org/10.3389/fonc.2022.1038890 Text en Copyright © 2022 Li, Wu and Ma https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Li, Na
Wu, Zhuanchang
Ma, Chunhong
ZHX2 in health and disease
title ZHX2 in health and disease
title_full ZHX2 in health and disease
title_fullStr ZHX2 in health and disease
title_full_unstemmed ZHX2 in health and disease
title_short ZHX2 in health and disease
title_sort zhx2 in health and disease
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718504/
https://www.ncbi.nlm.nih.gov/pubmed/36465389
http://dx.doi.org/10.3389/fonc.2022.1038890
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